H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH

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H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH Basic information
Product Name:H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH
Synonyms:PKC SUBSTRATE PEPTIDE;PROTEIN KINASE C SUBSTRATE PEPTIDE;QKRPSQRSKYL;MYELIN BASIC PROTEIN (4-14);MYELIN BASIC PROTEIN (4-14) (2);MYELIN BASIC PROTEIN (4-14) (BOVINE);MYELIN BASIC PROTEIN FRAGMENT 4-14;L-Gln-L-Lys-L-Arg-L-Pro-L-Ser-L-Gln-L-Arg-L-Ser-L-Lys-L-Tyr-L-Leu-OH
CAS:126768-94-3
MF:C60H103N21O17
MW:1390.59
EINECS:
Product Categories:Peptide;Myelin-Associated GlycoproteinEnzyme Substrates;Protein Kinase C (PKC)Peptides for Cell Biology;Protein Kinase CSerine/Threonine Kinase Biology;Protein Kinase Related Peptides;Protein Kinase Substrates;Proteins and Derivatives;Serine/Threonine Kinase Substrates;Structural Proteins;Substrates by Enzyme
Mol File:126768-94-3.mol
H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH Structure
H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH Chemical Properties
density 1.51±0.1 g/cm3(Predicted)
storage temp. −20°C
pka3.37±0.10(Predicted)
form Solid
color White to off-white
SequenceGln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
SigmaAldrich English
H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH Usage And Synthesis
UsesMyelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts[1][2].
Biological ActivityProtein Target: PKC', 'Target Sub-Family: AGC
References[1] Farrar YJ, et al. A phosphatase resistant substrate for the assay of protein kinase C in crude tissue extracts. Biochem Biophys Res Commun. 1991;180(2):694-701. DOI:10.1016/s0006-291x(05)81121-0
[2] Yasuda I, et al. A synthetic peptide substrate for selective assay of protein kinase C. Biochem Biophys Res Commun. 1990;166(3):1220-1227. DOI:10.1016/0006-291x(90)90996-z
H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH Preparation Products And Raw materials
Tag:H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH(126768-94-3) Related Product Information
H-Glu-Ala-Asp-Pro-Thr-Gly-His-Ser-Tyr-OH 1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy MBP 4-14 (Des-Tyr1)-Leu-enkephalin H-Ala-Ala-Tyr-Ala-OH H-Ala-Ala-Ala-Tyr-Ala-OH H-Tyr-Leu-OH H-Phe-Leu-OH (Ac-Gln4)-myelin basic protein (4-14) H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH