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| | H-Tyr-Leu-OH Basic information |
| Product Name: | H-Tyr-Leu-OH | | Synonyms: | L-TYROSYL-L-LEUCINE;TYR-LEU 99% CRYSTALLINE;tyr-leucrystalline;L-Leucine, N-L-tyrosyl-;(S)-2-((S)-2-AMino-3-(4-hydroxyphenyl)propanaMido)-4-Methylpentanoic acid;L-Leucine, L-tyrosyl-;(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoic acid;TYR-LEU | | CAS: | 17355-10-1 | | MF: | C15H22N2O4 | | MW: | 294.35 | | EINECS: | | | Product Categories: | Dipeptides;Dipeptides and Tripeptides;Peptides | | Mol File: | 17355-10-1.mol |  |
| | H-Tyr-Leu-OH Chemical Properties |
| Melting point | 280 °C (sublm)(Solv: water (7732-18-5)) | | Boiling point | 575.9±50.0 °C(Predicted) | | density | 1.218±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | pka | 3.12±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | H-Tyr-Leu-OH Usage And Synthesis |
| Uses | (S)-2-((S)-2-Amino-3-(4-hydroxyphenyl)propanamido)-4-methylpentanoic Acid is a pharmaceutical agent with ACE inhibitory properties. | | Definition | ChEBI: A dipeptide formed from L-tyrosine and L-leucine residues. | | in vivo | Tyrosylleucine (YL), administered orally, intracerebroventricularly, or intraperitoneally exhibits a potent antidepressant-like activity in the forced swim and tail suspension tests in na ve mice[1]. | Animal Model: | Male ddY mice (24-27g)[1] | | Dosage: | 0.1-30mg/kg, i.p.; 0.1-1.0 nmol/mouse, i.c.v.; 30-100mg/kg, p.o. | | Administration: | Administered orally, intracerebroventricularly, or intraperitoneally | | Result: | Decreased immobility time after intraperitoneal (1-30mg/kg) and intracerebroventricular (0.3-1 nmol/mouse) administrations in the FST.
Exhibited a potent antidepressant-like activity in the forced swim and tail suspension tests in nave mice.
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| | H-Tyr-Leu-OH Preparation Products And Raw materials |
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