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| | KN93 hydrochloride Basic information |
| Product Name: | KN93 hydrochloride | | Synonyms: | KN 93 hydrochloride;KN-93 (hydrochloride);KN93 hydrochloride;KN-93 HCl;CS-1449;KN93 (HCI);KN-93 (HCI);KN-93 HCI | | CAS: | 1956426-56-4 | | MF: | C26H29ClN2O4S.ClH | | MW: | 537.5 | | EINECS: | | | Product Categories: | | | Mol File: | 1956426-56-4.mol |  |
| | KN93 hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF:10.0(Max Conc. mg/mL);18.6(Max Conc. mM)
DMSO:20.5(Max Conc. mg/mL);38.14(Max Conc. mM)
Water:0.45(Max Conc. mg/mL);0.84(Max Conc. mM) | | form | A crystalline solid | | color | White to off-white |
| | KN93 hydrochloride Usage And Synthesis |
| Uses | KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM. | | Biological Activity | KN93 hydrochloride is a cell-permeable, reversible and competitive inhibitor of calmodulin-dependent kinase type II (CaMKII) with Ki of 370 nM. | | in vitro | After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN93 release, a peak of cells had progressed into S and G2-M. KN93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. | | target | | | IC 50 | CaMK II | | References | [1] Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995 Sep;6(9):1063-70. PMID:8519682
[2] Li J, et al. Curcumin Attenuates Retinal Vascular Leakage by Inhibiting Calcium/Calmodulin-Dependent Protein Kinase II Activity in Streptozotocin-Induced Diabetes. Cell Physiol Biochem. 2016;39(3):1196-208. DOI:10.1159/000447826
[3] Mamiya N, et al. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitorKN-93. Biochem Biophys Res Commun. 1993 Sep 15;195(2):608-15. DOI:10.1006/bbrc.1993.2089
[4] Anderson ME, et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006. PMID:9864285 |
| | KN93 hydrochloride Preparation Products And Raw materials |
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