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PCI 29732

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Company Name: Shanghai Boyle Chemical Co., Ltd.  
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  • PCI 29732
  • PCI 29732 pictures
  • $43.00
  • 2026-07-27
  • CAS:330786-25-9
  • Purity: 99.81%
  • Supply Ability: 10g
PCI 29732 Basic information
Product Name:PCI 29732
Synonyms:PCI 29732;4-Amino-1-cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine;1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;PCI 29732 (This product is only available in Japan.);CS-2698;PCI 29732;PCI29732;PCI-29732;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-cyclopentyl-3-(4-phenoxyphenyl)-;cytotoxicity,Bruton tyrosine kinase,Inhibitor,Btk,ABCG2,reversible,PCI 29732,BCR,inhibit,B-cell,BCRP,oral,Breast cancer resistance protein
CAS:330786-25-9
MF:C22H21N5O
MW:371.43
EINECS:
Product Categories:
Mol File:330786-25-9.mol
PCI 29732 Structure
PCI 29732 Chemical Properties
Boiling point 599.6±50.0 °C(Predicted)
density 1.36±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
pka4.24±0.30(Predicted)
form Powder
color White to off-white
Safety Information
MSDS Information
PCI 29732 Usage And Synthesis
UsesPCI 29732 (cas# 330786-25-9) is a useful research chemical. It is a COVID19-related research product.
DefinitionChEBI: 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is an aromatic ether.
in vivo

PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP-binding site of ABCG2 and enhances the anti-tumor efficacy of substrate chemotherapeutic agents[2].
PCI 29732 (20 mg/kg; p.o.; every 3 d × 5 times) enhances the anticancer efficacy of Topotecan in the H460/MX20 cell xenograft nude mice model[2].

Animal Model:5-6 weeks old athymic nude mice (bearing H460/MX20 cells)[2]
Dosage:20 mg/kg (combination with Topotecan; every 3 d × 5 times, i.p., 3 mg/kg; topotecan was given 1 h after PCI29732 administration)
Administration:P.o.; every 3 d × 5 times
Result:Significant reductions in tumor weight and volume were observed in the group treated with PCI29732 in combination with Topotecan.
storageStore at +4°C
PCI 29732 Preparation Products And Raw materials
Tag:PCI 29732(330786-25-9) Related Product Information
1-(1-Methylethyl)-3-(2-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 3-(6-Ethoxy-2-naphthalenyl)-1-(4-piperidinylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one 4-AMino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyriMidine Cyclohexanol, 4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-methyl-, cis- 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(4-phenoxyphenyl)-