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| | 20-(tert-Butoxy)-20-oxoicosanoic acid Basic information |
| Product Name: | 20-(tert-Butoxy)-20-oxoicosanoic acid | | Synonyms: | 20-(tert-Butoxy)-20-oxoicosanoic acid;20-(tert-Butoxy)-20-Eicosanedioic Acid;Eicosandioic acid, 1-(1,1-dimethyl) ester;20-[(2-methylpropan-2-yl)oxy]-20-oxoicosanoic acid;20-(tert-Butoxy)-20-Eicosanedioic Aci;Eicosanedioic acid 1-tert-butyl ester;Eicosanedioic acid, 1-(1,1-dimethylethyl) ester;20-(tert-Butoxy)-20-oxoicosanoic acid ISO 9001：2015 REACH | | CAS: | 683239-16-9 | | MF: | C24H46O4 | | MW: | 398.62 | | EINECS: | 202-303-5 | | Product Categories: | 683239-16-9 | | Mol File: | 683239-16-9.mol |  |
| | 20-(tert-Butoxy)-20-oxoicosanoic acid Chemical Properties |
| Boiling point | 496.0±18.0 °C(Predicted) | | density | 0.942±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | Solid | | pka | 4.78±0.10(Predicted) | | color | White to off-white | | InChI | InChI=1S/C24H46O4/c1-24(2,3)28-23(27)21-19-17-15-13-11-9-7-5-4-6-8-10-12-14-16-18-20-22(25)26/h4-21H2,1-3H3,(H,25,26) | | InChIKey | JUCDAUSILDWYOA-UHFFFAOYSA-N | | SMILES | C(OC(C)(C)C)(=O)CCCCCCCCCCCCCCCCCCC(O)=O | | CAS DataBase Reference | 683239-16-9 |
| | 20-(tert-Butoxy)-20-oxoicosanoic acid Usage And Synthesis |
| Description | 20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and in the synthesis of PROTACs. | | Chemical Properties | Eicosanedioic acid mono-tert-butyl ester is a solid at room temperature and pressure, with poor solubility in water but some solubility in alcohol organic solvents. It has certain acidity, and the carboxyl unit at one end of the alkyl chain in its structure can be esterified with alcohol compounds under the action of acid catalyst to obtain the corresponding diester derivatives. | | Uses | 20-(tert-Butoxy)-20-oxoicosanoic acid is a useful research chemical compound. | | Uses |
20-(tert-Butoxy)-20-oxoicosanoic acid (CAS 683239-16-9) is a high-purity (99%) long-chain aliphatic coupling agent. Its molecular structure features orthogonal protective groups at both ends: one end contains a reactive free carboxyl group, whilst the other end contains a carboxyl group protected by a tert-butyl ester (-tBu). Under the action of a suitable catalyst, the carboxylic acid can undergo a condensation reaction with the amino group of the lysine (Lys) side chain in a peptide, and is used in the preparation of bioactive molecules.
| | Synthesis | 20-(tert-Butoxy)-20-oxoicosanoic acid can be prepared from eicosanedioic acid by esterification. | | IC 50 | Non-cleavable Linker |
| | 20-(tert-Butoxy)-20-oxoicosanoic acid Preparation Products And Raw materials |
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