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BOC Sciences |
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1-631-485-4226; 16314854226 |
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LP 533401 manufacturers
- LP-533401
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- $4300.00
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2026-04-20
- CAS:945976-43-2
- Purity:
- Supply Ability: 10g
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| | LP 533401 Basic information |
| Product Name: | LP 533401 | | Synonyms: | LP 533401;LP-533401 /L-Phenylalanine, 4-[2-amino-6-[2,2,2-trifluoro-1-(3'-fluoro[1,1'-biphenyl]-4-yl)ethoxy]-4-pyrimidinyl]-;L-Phenylalanine, 4-[2-amino-6-[2,2,2-trifluoro-1-(3\'-fluoro[1,1\'-biphenyl]-4-yl)ethoxy]-4-pyrimidinyl]-;LP 533401; LP533401;(2S)-2-amino-3-[4-[2-amino-6-[2,2,2-trifluoro-1-[4-(3-fluorophenyl)phenyl]ethoxy]pyrimidin-4-yl]phenyl]propanoic acid;CS-2152;LP-533401 (free base);(2S)-2-Amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3'-fluoro-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid | | CAS: | 945976-43-2 | | MF: | C27H22F4N4O3 | | MW: | 526.48 | | EINECS: | | | Product Categories: | | | Mol File: | 945976-43-2.mol |  |
| | LP 533401 Chemical Properties |
| Boiling point | 699.0±65.0 °C(Predicted) | | density | 1.388±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 5 mg/ml | | form | A crystalline solid | | pka | 2.04±0.10(Predicted) | | color | Brown to breen |
| | LP 533401 Usage And Synthesis |
| Uses | LP 533401 inhibits tryptophan hydroxylase 1 (Tph1) which is the rate-limiting enzyme responsible for serotonin production. | | in vivo | Oral administration once daily for up to 6 weeks of this small molecule prevents the development of and fully rescues, in a dose-dependent manner, osteoporosis in ovariectomized rodents because of an isolated increase in bone formation. Pharmacokinetic studies in rodents show that LP-533401 level in the brain is negligible following oral administration, indicating that it is virtually unable to cross the blood-brain barrier[1]. Mice treated repeatedly with LP-533401 (30–250 mg/kg per day) exhibit marked 5-HT content reductions in the gut, lungs, and blood, but not in the brain. After a single LP533401 dose (250 mg/kg), lung and gut 5-HT contents decrease by 50%, whereas blood 5-HT levels remain unchanged, suggesting gut and lung 5-HT synthesis[2]. Adult, healthy mice treated with the Tph-1 inhibitor LP-533401 show 30% decrease in circulating serotonin levels, with a consequent 30% increase in osteoblast numbers. Administration of LP533401 to mice injected with EL4 cells inhibits the decrement in osteoblast numbers and trabecular bone volume, prolongs survial, and decreases leukemic infiltration[3]. |
| | LP 533401 Preparation Products And Raw materials |
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