(S)-(-)-5-Fluorowillardiine (hydrochloride)

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(S)-(-)-5-Fluorowillardiine (hydrochloride) Basic information
Product Name:(S)-(-)-5-Fluorowillardiine (hydrochloride)
Synonyms:(S)-(-)-5-Fluorowillardiine (hydrochloride);(5S)-Fluorowillardiine hydrochloride;(S) ( ) 5 Fluorowillardiine hydrochloride,(S)()5Fluorowillardiine hydrochloride
CAS:1321546-70-6
MF:C7H8FN3O4.ClH
MW:253.62
EINECS:
Product Categories:
Mol File:1321546-70-6.mol
(S)-(-)-5-Fluorowillardiine (hydrochloride) Structure
(S)-(-)-5-Fluorowillardiine (hydrochloride) Chemical Properties
storage temp. Store at -20°C
solubility Water: Soluble
form Solid
color White to off-white
Water Solubility Water: 6.67 mg/mL (26.30 mM)
Safety Information
MSDS Information
(S)-(-)-5-Fluorowillardiine (hydrochloride) Usage And Synthesis
Uses(S)-(-)-5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist.
References[1] Hawkinson JE, et al. Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding. Eur J Pharmacol. 1997 Jun 25;329(2-3):213-21. PMID:9226415
[2] Kessler M, et al. Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators. Brain Res. 2006 Mar 3;1076(1):25-41. DOI:10.1016/j.brainres.2005.09.024
[3] Rembach A, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004 Aug 15;77(4):573-82. DOI:10.1002/jnr.20191
[4] JEREMY R. GREENWOOD . 3-Hydroxypyridazine 1-oxides as carboxylate bioisosteres: A new series of subtype-selective AMPA receptor agonists[J]. Neuropharmacology, 2006, 51 1: Pages 52-59. DOI: 10.1016/j.neuropharm.2006.02.013
[5] JIN ZHAI  Armando L  Ying Ying Zhou. Sensitivity, specificity and limitation of in vitro hippocampal slice and neuron-based assays for assessment of drug-induced seizure liability[J]. Toxicology and applied pharmacology, 2021, 430: Article 115725. DOI: 10.1016/j.taap.2021.115725
[6] JARI A. LARM  Philip M B  Nam Sang Cheung. (S)-5-Fluorowillardiine-mediated neurotoxicity in cultured murine cortical neurones occurs via AMPA and kainate receptors[J]. European journal of pharmacology, 1996, 314 1: Pages 249-254. DOI: 10.1016/s0014-2999(96)00633-4
(S)-(-)-5-Fluorowillardiine (hydrochloride) Preparation Products And Raw materials
Tag:(S)-(-)-5-Fluorowillardiine (hydrochloride)(1321546-70-6) Related Product Information
3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid (S)-(-)-5-Fluorowillardiine (hydrochloride) S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid ethyl 3-(5-fluoro-2,4-dioxopyrimidin-1-yl)propanoate 1(2H)-Pyrimidinepropanoic acid, alpha-amino-3,4-dihydro-3-methyl-2,4-dioxo-, (alphaS)- (9CI) 2-Amino-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid