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S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid manufacturers
- (S)-Willardiine
-
- $50.00
-
2026-09-10
- CAS:21416-43-3
- Purity: 99.85%
- Supply Ability: 10g
- (S)-Willardiine
-
- $50.00
-
2026-04-20
- CAS:21416-43-3
- Purity: 99.85%
- Supply Ability: 10g
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| | S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid Basic information |
| Product Name: | S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid | | Synonyms: | L-WILLARDIINE;S(-)-WILLARDIINE;S(-)-WILLARDIINE AMPA/KAINATE AGONIST;S(-)-α-Amino--3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid;(2S)-2-Amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1-yl)propionic acid;(S)-2-Amino-3-[2,4-dioxo-3,4-dihydropyrimidine-1(2H)-yl]propanoic acid;3-[(2,4-Dioxo-1,2,3,4-tetrahydropyrimidine)-1-yl]-L-alanine;Willardine | | CAS: | 21416-43-3 | | MF: | C7H9N3O4 | | MW: | 199.16 | | EINECS: | | | Product Categories: | Glutamate | | Mol File: | 21416-43-3.mol |  |
| | S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid Chemical Properties |
| Melting point | 204-205 °C | | storage temp. | 2-8°C(protect from light) | | solubility | 0.1 M NaOH: 7.2 mg/mL | | density | 1.501±0.06 g/cm3(Predicted) | | pKa | 2.12±0.10(Predicted) | | form | solid | | color | white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid Usage And Synthesis |
| Description | This simple base occurs in germinatine pea seeds or seedlings. The structure
given above has been determined from chemical and s'pectroscopic analysis. | | Uses | (S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.
IC50 value: 44.8 uM(EC50) [1]
Target: AMPA/kainate receptor agonist
in vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses [1]. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% [2].
in vivo: In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists [3]. | | Definition | ChEBI: 3-(uracil-1-yl)-L-alanine is the 3-(uracil-1-yl) derivative of L-alanine. It is a non-proteinogenic L-alpha-amino acid and a L-alanine derivative. It is functionally related to a uracil. It is a tautomer of a 3-(uracil-1-yl)-L-alanine zwitterion. | | IC 50 | Kainate Receptor | | References | Ashworth, Brown, Roberts., Biochern J., 129,897 (1972) |
| | S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid Preparation Products And Raw materials |
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