| Company Name: |
Haoyuan Chemexpress Co., Ltd.
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| Tel: |
021-58950125 |
| Email: |
info@chemexpress.com |
| Products Intro: |
Product Name:Pyr6
CAS:245747-08-4
Purity:>98% Package:1760RMB/10mg
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Pyr6 manufacturers
- Pyr6
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- $31.00 / 5mg
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2026-05-11
- CAS:245747-08-4
- Min. Order:
- Purity: 99.18%
- Supply Ability: 10g
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| Product Name: | Pyr6 | | Synonyms: | Pyr6;N-{4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-3-fluoroisonicotinamide;N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide;4-Pyridinecarboxamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-;Pyr6 >=98% (HPLC);Pyr6,Inhibitor,TRP Channel,inhibit,Pyr 6,Pyr-6,Transient receptor potential channels;Pyr6, 10 mM in DMSO | | CAS: | 245747-08-4 | | MF: | C17H9F7N4O | | MW: | 418.27 | | EINECS: | | | Product Categories: | | | Mol File: | 245747-08-4.mol |  |
| Melting point | 162-163 °C | | Boiling point | 368.4±42.0 °C(Predicted) | | density | 1.52±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 100 mg/mL (239.08 mM) | | form | Solid | | pka | 9.85±0.70(Predicted) | | color | Light yellow to yellow | | InChI | 1S/C17H9F7N4O/c18-12-8-25-6-5-11(12)15(29)26-9-1-3-10(4-2-9)28-14(17(22,23)24)7-13(27-28)16(19,20)21/h1-8H,(H,26,29) | | InChIKey | XZIQSOZOLJJMFN-UHFFFAOYSA-N | | SMILES | O=C(C1=CC=NC=C1F)NC2=CC=C(N3C(C(F)(F)F)=CC(C(F)(F)F)=N3)C=C2 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| Uses | Pyr6 is a selective store operated calcium entry (SOCE) inhibitor with an IC50 of 0.49 μM. Pyr6 displays 37-fold higher potency for RBL SOCE than for TRPC3 ROCE[1]. | | Biological Activity | Pyr6 is a selective inhibitor of calcium release from the endoplasmic reticulum via STIM1/Orai1 mediated, store operated calcium entry (SOCE). Pyr6 blocks SOCE in thapsigargin treated, calcium depleted BRL-2H3 cells (IC50 = 0.49 μM), but has poor activity against carbachol-induced, TRPC3-mediated calcium entry in TRPC3-transfected HEK293 cells (IC50 = 18.46 μM). | | References | [1] Schleifer H, et al. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways. Br J Pharmacol. 2012 Dec;167(8):1712-22. DOI:10.1111/j.1476-5381.2012.02126.x |
| | Pyr6 Preparation Products And Raw materials |
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