(S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate

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(S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate manufacturers

  • BMS-466442
  • BMS-466442 pictures
  • $983.00
  • 2026-05-11
  • CAS:1598424-76-0
  • Purity:
  • Supply Ability: 10g
(S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate Basic information
Product Name:(S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate
Synonyms:(S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate;spudl 05650;L-Histidine, N-[[5-methoxy-6-(phenylmethoxy)-1H-indol-2-yl]carbonyl]-1-(phenylmethyl)-, methyl ester;BMS466442,BMS 466442;3-(1-Benzyl-1H-imidazol-4-yl)-2(S)-[(6-benzyloxy-5-methoxy-1H-indole-2-carbonyl)-amino]-propionic acid methyl ester
CAS:1598424-76-0
MF:C31H30N4O5
MW:538.59
EINECS:
Product Categories:
Mol File:1598424-76-0.mol
(S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate Structure
(S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate Chemical Properties
Boiling point 827.3±65.0 °C(Predicted)
density 1.26±0.1 g/cm3(Predicted)
storage temp. -10 to -25°C
solubility Soluble to 100 mM in DMSO
pka13.15±0.46(Predicted)
form Solid
color Off-white to yellow
InChIKeyUUCAHZCMRZOTNF-MHZLTWQESA-N
SMILESCOC([C@H](CC1=CN(C=N1)CC2=CC=CC=C2)NC(C(NC3=C4)=CC3=CC(OC)=C4OCC5=CC=CC=C5)=O)=O
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
(S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate Usage And Synthesis
UsesBMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research[1][2].
Biological ActivityPotent and selective alanine serine cysteine transporter-1 (ASC-1; SLC7A10) inhibitor th at effectively blocks ASC-1-mediated cellular D-Ser uptake.



BMS-466442 is a selective alanine serine cysteine transporter-1 (ASC-1) inhibitor (D-Ser uptake IC50 = 36.8 nM and 19.7 nM using HEK human ASC-1 transfectants or primary r at embryonic cortical cultures, respectively) with good selectivity over >40 other targets, including LAT-2 or ASCT-2 (IC50 >10 μM).
IC 50α adrenergic receptor: ≥10 μM (IC50); ASCT1: 1 nM (IC50)
storageStore at -20°C
References[1] Brown JM, et al. In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10). J Neurochem. 2014 Apr;129(2):275-83. DOI:10.1111/jnc.12618
[2] Torrecillas IR, et al. Inhibition of the Alanine-Serine-Cysteine-1 Transporter by BMS-466442. ACS Chem Neurosci. 2019 May 15;10(5):2510-2517. DOI:10.1021/acschemneuro.9b00019
(S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate Preparation Products And Raw materials
Tag:(S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate(1598424-76-0) Related Product Information
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