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| | ALPHA-BUNGAROTOXIN Basic information |
| Product Name: | ALPHA-BUNGAROTOXIN | | Synonyms: | ALPHA-BUNGAROTOXIN;ALPHA-BUNGAROTOXIN, BUNGARUS MULTICINCTUS;ALPHA-BUTX;ALPHA-BGT;A-BUNGAROTOXIN;M.W. 7984.14 C338H529N97O105S11;H-ILE-VAL-CYS-HIS-THR-THR-ALA-THR-SER-PRO-ILE-SER-ALA-VAL-THR-CYS-PRO-PRO-GLY-GLU-ASN-LEU-CYS-TYR-ARG-LYS-MET-TRP-CYS-ASP-ALA-PHE-CYS-SER-SER-ARG-GLY-LYS-VAL-VAL-GLU-LEU-GLY-CYS-ALA-ALA-THR-CYS-PRO-SER-LYS-LYS-PRO-TYR-GLU-GLU-VAL-THR-CYS-CYS-SER-THR-ASP-LYS-CYS-ASN-PRO-HIS-PRO-LYS-GLN-ARG-PRO-GLY-OH;BUNGARUS MULTICINCTUS TOXIN, ALPHA | | CAS: | 11032-79-4 | | MF: | C50H70O14 | | MW: | 895.0824 | | EINECS: | 234-266-6 | | Product Categories: | Acetylcholine receptor | | Mol File: | 11032-79-4.mol |  |
| | ALPHA-BUNGAROTOXIN Chemical Properties |
| storage temp. | −20°C | | solubility | Soluble in sterile water | | form | solid | | color | white | | Water Solubility | Soluble in water | | Sequence | Ile-Val-Cys-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys-Pro-Pro-Gly-Glu-Asn-Leu-Cys-Tyr-Arg-Lys-Met-Trp-Cys-Asp-Ala-Phe-Cys-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys-Ala-Ala-Thr-Cys-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys-Cys-Ser-Thr-Asp-Lys-Cys-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly (Disulfide bridge: Cys3-Cys23;Cys16-Cys44;Cys29-Cys33;Cys48-Cys59;Cys60-Cys65) | | InChIKey | LYTCVQQGCSNFJU-UHFFFAOYSA-N | | CAS DataBase Reference | 11032-79-4 |
| WGK Germany | 3 | | RTECS | QQ4495249 | | Storage Class | 11 - Combustible Solids | | Toxicity | chicken,LD50,intramuscular,74ug/kg (0.074mg/kg),Toxicon. Vol. 7, Pg. 89, 1969. |
| | ALPHA-BUNGAROTOXIN Usage And Synthesis |
| Chemical Properties | Single polypeptide weight; molecular
weight of 8000. | | Uses | A polypeptide composed of 74 amino acids containing 5 disulfide bridges. Blocks neuromuscular transmission by irreversible binding to the motor end-plate acetylcholine receptor (Kd = 1 nM to 1 pM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced augmentation in intracellular Ca2+ in PC12 cells (IC50 = 310 nM). Prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-Bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 µM).
Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 µM). | | Definition | A protein that binds specifically to acetylcholine
receptors. | | General Description | Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 μM). | | Hazard | Nuerotoxic. | | Biochem/physiol Actions | Product does not compete with ATP. | | storage | -20°C (desiccate) |
| | ALPHA-BUNGAROTOXIN Preparation Products And Raw materials |
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