AZD-5582 manufacturers
- AZD5582
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- $49.00
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2026-07-27
- CAS:1258392-53-8
- Purity: 98.75%
- Supply Ability: 10g
- AZD5582
-
- $49.00
-
2026-07-16
- CAS:1258392-53-8
- Purity: 98.75%
- Supply Ability: 10g
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| | AZD-5582 Basic information |
| Product Name: | AZD-5582 | | Synonyms: | AZD-5582;3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide];AZD5582;AZD-5582;AZD 5582;CS-2673;(S,S,2S,2'S)-N,N'-((1S,1'S,2R,2'R)-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide);L-Prolinamide, 3,3'-[2,4-hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-;ZD5582;(2S,2'S)-1,1'-((S,2S,2'S)-2,2'-(((1S,1'S,2R,2'R)-(Hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(cyclohexane-3,1-diyl))bis(2-((S)-2-(methylamino)propanamido)acetyl))bis(pyrrolidine-2-carboxamide) | | CAS: | 1258392-53-8 | | MF: | C58H78N8O8 | | MW: | 1015.29 | | EINECS: | | | Product Categories: | | | Mol File: | 1258392-53-8.mol |  |
| | AZD-5582 Chemical Properties |
| Boiling point | 1207.3±65.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light, stored under nitrogen | | solubility | DMF: 30 mg/ml; DMSO: 15 mg/ml; Ethanol: 30 mg/ml | | form | A crystalline solid | | pka | 12.99±0.40(Predicted) | | color | White to yellow | | InChIKey | BRCXWBBDZROUEZ-WCMFYDHYSA-N |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | AZD-5582 Usage And Synthesis |
| Uses | It is a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer. | | Biological Activity | AZD5582 is a divalent AVPI motif-based Smac (DIABLO) mimetic (SMC) th at acts a potent apoptosis protein repe at (BIR) domain-targeting antagonist against inhibitor of apoptosis proteins (IAPs) cIAP1/2 (BIR3 IC50 = 15/21 nM against 2.5 nM AbuRPFK-5FAM) and XIAP (BIR2/3 IC50 = 21/15 nM). AZD5582 abolishes cellular XIAP-caspase-9 interaction (1 μM, 4 hrs), induces cIAP1/2 degradation (EC50 = 0.1 nM, 1 hr) and apoptosis (GI50 <60 pM, 48 hrs) in MDA-MB-231 breast cancer cultures. AZD5582 causes substantial tumor regression by inducing cIAP1 degradation and apoptosis in tumor cells in MDA-MB-231 xenograft-bearing mice in vivo (3.0 mg/kg/wk i.v.). | | in vivo | AZD5582 (intravenous injection; 0.1-3.0 mg/kg; once a week; 2 weeks) causes degradation of cIAP1 and caspase 3 cleavage in tumor cells, and after a two-week treatment, the tumors largely resolved; when the mice are given a medium dose (0.5 mg/kg) of AZD5582, cIAP1 degrades after administration, but it takes a while time to reach apoptosis-inducing effect[1]. | Animal Model: | MDA-MB-231 xenograft-bearing mice[1] | | Dosage: | 0.1 mg/kg, 0.5 mg/kg, 3.0 mg/kg | | Administration: | Intravenous injection; once a week; 2 weeks | | Result: | Resulted in cIAP1 degradation and caspase-3 cleavage within tumor cells and causes substantial tumor regressions following two weekly doses of 3.0 mg/kg |
| | IC 50 | cIAP1: 15 nM (IC50); cIAP2: 21 nM (IC50); XIAP: 15 nM (IC50) |
| | AZD-5582 Preparation Products And Raw materials |
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