NoxA1ds

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NoxA1ds Suppliers list
Company Name: Nanjing Chemlin Chemical Co., Ltd  
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NoxA1ds Basic information
Product Name:NoxA1ds
Synonyms:NoxA1ds;(4S)-4-amino-5-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-oxopentanoic acid;NoxA1ds TFA
CAS:1435893-78-9
MF:C50H88N14O15
MW:1125.32
EINECS:
Product Categories:
Mol File:1435893-78-9.mol
NoxA1ds Structure
NoxA1ds Chemical Properties
solubility Soluble in DMSO
form Solid
color White to off-white
SequenceH-Glu-Pro-Val-Asp-Ala-Leu-Gly-Lys-Ala-Lys-Val-NH2
Safety Information
MSDS Information
NoxA1ds Usage And Synthesis
UsesNoxA1ds is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM). NoxA1ds inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds can be used in the study of hypertension, atherosclerosis and tumors[1].
IC 50NOX1
References[1] Ranayhossaini DJ, et al. Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J Biol Chem. 2013;288(51):36437-36450. DOI:10.1074/jbc.M113.521344
NoxA1ds Preparation Products And Raw materials
Tag:NoxA1ds(1435893-78-9) Related Product Information
2-(2-chlorophenyl)-4-Methyl-5-(pyridin-2-ylMethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione APX-115 Y-27632 GSK2795039 NoxA1ds 1-Oleoyl-2-hydroxy-sn-glycero-3[phospho-L-serine](sodium salt)