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| | Benzyloxy carbonyl-PEG3-acid Basic information |
| Product Name: | Benzyloxy carbonyl-PEG3-acid | | Synonyms: | Benzyloxy carbonyl-PEG3-acid;Benzyloxy carbonyl-PEG3-C2-acid;4,7,10,14-Tetraoxapentadecanoic acid, 13-oxo-15-phenyl-;3-Oxo-1-phenyl-2,6,9,12-tetraoxapentadecan-15-oic acid | | CAS: | 2100306-73-6 | | MF: | C17H24O7 | | MW: | 340.37 | | EINECS: | | | Product Categories: | | | Mol File: | 2100306-73-6.mol |  |
| | Benzyloxy carbonyl-PEG3-acid Chemical Properties |
| Boiling point | 494.9±40.0 °C(Predicted) | | density | 1.181±0.06 g/cm3(Predicted) | | pka | 4.28±0.10(Predicted) |
| | Benzyloxy carbonyl-PEG3-acid Usage And Synthesis |
| Description | Benzyloxy carbonyl-PEG3-acid is a PEG linker with a benzyl protecting group and a carboxylic acid moiety. The carboxylic acid can undergo reactions with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The benzyl protecting group can be removed via hydrogenolysis. The hydrophilic PEG linker increases the water solubility of the compound. | | Uses | Benzyloxy carbonyl-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Benzyloxy carbonyl-PEG3-acid Preparation Products And Raw materials |
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