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| | Benzyloxy carbonyl-PEG3-t-butyl ester Basic information |
| Product Name: | Benzyloxy carbonyl-PEG3-t-butyl ester | | Synonyms: | Benzyloxy carbonyl-PEG3-t-butyl ester;Benzyloxy carbonyl-PEG3-C2-Boc;benzyl 3-[2-[2-(3-tert-butoxy-3-oxo-propoxy)ethoxy]ethoxy]propanoate;4,7,10,14-Tetraoxahexadecanoic acid, 15,15-dimethyl-13-oxo-, phenylmethyl ester | | CAS: | 1835759-86-8 | | MF: | C21H32O7 | | MW: | 396.47 | | EINECS: | | | Product Categories: | | | Mol File: | 1835759-86-8.mol |  |
| | Benzyloxy carbonyl-PEG3-t-butyl ester Chemical Properties |
| Boiling point | 476.1±35.0 °C(Predicted) | | density | 1.092±0.06 g/cm3(Predicted) |
| | Benzyloxy carbonyl-PEG3-t-butyl ester Usage And Synthesis |
| Description | Benzyloxy carbonyl-PEG3-t-butyl ester is a PEG linker containing a benzyloxy carbonyl group and a t-butyl ester protecting group. The benzyloxy carbonyl helps to enhance chemoselectivity of a reaction. The t-butyl ester can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | | Uses | Benzyloxy carbonyl-PEG3-C2-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Benzyloxy carbonyl-PEG3-t-butyl ester Preparation Products And Raw materials |
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