- COOH-PEG3-COOMe
-
-
2025-06-07
- CAS:1807505-26-5
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
|
| | Acid-PEG3-mono-methyl ester Basic information |
| Product Name: | Acid-PEG3-mono-methyl ester | | Synonyms: | Acid-PEG3-mono-methyl ester;CARBOXY-PEG3-MONO-METHYL ESTER;CAS_1807505-26-5;COOH-PEG3-COOMe;4,7,10,14-Tetraoxapentadecanoic acid, 13-oxo-;MeOOCCH2CH2O-PEG2-CH2CH2COOH;MeOOCCH2CH2O-PEG2-CH2CH2COOH/4,7,10,14-Tetraoxapentadecanoic acid, 13-oxo-;COOH-PEG3-CH2CH2COOMe | | CAS: | 1807505-26-5 | | MF: | C11H20O7 | | MW: | 264.27 | | EINECS: | | | Product Categories: | | | Mol File: | 1807505-26-5.mol |  |
| | Acid-PEG3-mono-methyl ester Chemical Properties |
| Boiling point | 396.7±32.0 °C(Predicted) | | density | 1.162±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Liquid | | pka | 4.27±0.10(Predicted) | | color | Colorless to light yellow |
| | Acid-PEG3-mono-methyl ester Usage And Synthesis |
| Description | Acid-PEG3-mono-methyl ester is a PEG linker with a carboxylic acid and methyl ester group. Methyl ester can be hydrolyzed under strong basic condition. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | | Uses | Acid-PEG3-mono-methyl ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Acid-PEG3-mono-methyl ester Preparation Products And Raw materials |
|