PC Mal-NHS carbonate ester manufacturers
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| | PC Mal-NHS carbonate ester Basic information |
| Product Name: | PC Mal-NHS carbonate ester | | Synonyms: | PC Mal-NHS carbonate ester;Carbonic acid, 1-[4-[4-[[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]amino]-4-oxobutoxy]-5-methoxy-2-nitrophenyl]ethyl 2,5-dioxo-1-pyrrolidinyl ester;1-(4-(4-((2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-4-oxobutoxy)-5-methoxy-2-nitrophenyl)ethyl (2,5-dioxopyrrolidin-1-yl) carbonate;1-[4-[4-[[2-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)ethyl]amino]-4-oxobutoxy]-5-methoxy-2-nitrophenyl]ethyl (2,5-Dioxo-1-pyrrolidinyl) Carbonate | | CAS: | 1408057-91-9 | | MF: | C24H26N4O12 | | MW: | 562.48 | | EINECS: | | | Product Categories: | | | Mol File: | 1408057-91-9.mol |  |
| | PC Mal-NHS carbonate ester Chemical Properties |
| density | 1.49±0.1 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | 15.25±0.46(Predicted) | | form | Solid | | color | White to off-white |
| | PC Mal-NHS carbonate ester Usage And Synthesis |
| Description | PC Mal-NHS carbonate ester is a photocleavable linker containing a Maleimide and an NHS ester groups. The maleimide group can react with thiol groups between pH 6.5 to 7.5. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | | Uses | PC Mal-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | | IC 50 | Cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | PC Mal-NHS carbonate ester Preparation Products And Raw materials |
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