863598-09-8
| 中文名称 | 863598-09-8 |
|---|---|
| 中文同义词 | 化合物CASEIN KINASE II INHIBITOR IV;3-(3-(2-((3,4,5-三甲氧基苯基)氨基)-7H-吡咯[2,3-D]嘧啶-7-基)苯基)丙腈;化合物CASEIN KINASE II INHIBITOR IV,10 MM DMSO 溶液;CASEIN KINASE II INHIBITOR IV |CAS 863598-09-8;角质形成细胞分化诱导剂 |
| 英文名称 | Casein Kinase II Inhibitor IV |
| 英文同义词 | Casein Kinase II Inhibitor IV;CK2-IN-1;Benzenepropanenitrile, 3-[2-[(3,4,5-trimethoxyphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-;3-[2-[(3,4,5-Trimethoxyphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]benzenepropanenitrile;3-(3-(2-((3,4,5-trimethoxyphenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)propanenitrile;Inhibitor,Casein Kinase,Casein Kinase II Inhibitor IV,inhibit;Keratinocyte Differentiation Inducer;3-(3-(2-((3,4,5-Trimethoxyphenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)propanenitrile , Casein Kinase II Inhibitor IV |
| CAS号 | 863598-09-8 |
| 分子式 | C24H23N5O3 |
| 分子量 | 429.47 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 863598-09-8.mol |
| 结构式 |  |
863598-09-8 性质
| 沸点 | 605.0±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.25±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥250 mg/ml（582.11mM） |
| 酸度系数(pKa) | 6.44±0.30(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
Target: Casein Kinase
Treatment of human epidermal keratinocytes (NHEKs) with Casein Kinase II Inhibitor IV leads to an increase in the early differentiation markers keratins 1 and 10 at 48 h. Increased levels of IVL and TGM are observed in cells treated with Casein Kinase II Inhibitor IV at 72 h and persisted at 96 h. In addition, treated with Casein Kinase II Inhibitor IV expressesloricrin, a terminal differentiation marker, at later time points. Similar results are observed by messenger RNA (mRNA) expression analysis of NHEKs treated with Casein Kinase II Inhibitor IV. At early time points (12 and 24 h), treatment with Casein Kinase II Inhibitor IV leads to the upregulation of keratinocyte early differentiation marker genes, including keratin 1 (5.4-fold) and keratin 10 (5.4-fold). Terminal differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are upregulated at late time points (36 and 48 h). These results are again consistent with the ability of Casein Kinase II Inhibitor IV to induce differentiation of epidermal progenitor cells into terminally differentiated keratinocytes.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-111378 | Casein Kinase II Inhibitor IV | 863598-09-8 | 1 mg | 748元 |
| 2026/09/15 | HY-111378 | 863598-09-8 Casein Kinase II Inhibitor IV | 863598-09-8 | 5mg | 2163元 |