N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride

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N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride Suppliers list
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N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride Basic information
Product Name:N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride
Synonyms:SCH 79797 DIHYDROCHLORIDE;N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diaminedihydrochloride;SCH797972HCl;N3-Cyclopropyl-7-(4-isopropylbenzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine;7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine,N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-;3-N-cyclopropyl-7-[(4-propan-2-ylphenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine;SCH 79797 dihydrochl;Sch 79797
CAS:245520-69-8
MF:C23H25N5
MW:371.48
EINECS:
Product Categories:Non-Chiral heterocyclic compounds;Pharmaceuticals;Proteinase-activated receptor (PAR)
Mol File:245520-69-8.mol
N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride Structure
N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride Chemical Properties
Boiling point 644.4±65.0 °C(Predicted)
density 1.32±0.1 g/cm3(Predicted)
storage temp. Desiccate at RT
solubility DMSO : 50 mg/mL (134.60 mM; Need ultrasonic)
pka8.73±0.40(Predicted)
form Solid
color Light yellow to brown
InChIKeyNNJTXSQXGHYXAJ-UHFFFAOYSA-N
SMILESCl.Cl.[n]2(c3c(c4c(nc(nc4N)NC5CC5)cc3)cc2)Cc1ccc(cc1)C(C)C
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride Usage And Synthesis
UsesSCH 79797 Dihydrochloride is a selective PAR1 antagonist.
DefinitionChEBI: N3-cyclopropyl-7-[(4-propan-2-ylphenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine is a member of quinazolines.
Biological ActivityPotent, selective non-peptide PAR 1 receptor antagonist (IC 50 = 70 nM). Inhibits haTRAP-induced- but not g-thrombin-, ADP- or collagen-induced human platelet aggregation. Also selectively blocks PAR 1 agonist- or thrombin-induced increases in cytosolic Ca 2+ in vascular smooth muscle cells.
in vivo

SCH79797 (2.5-250 μg/kg; intravenous injection; male Sprague Dawley rats) treatment immediately before or during ischemia reduces myocardial necrosis following I/R in the intact rat heart in two rat models of myocardial ischemia/reperfusion (I/R) injury. This response is dose-dependent with the optimal dose being 25 μg/kg[4].

Animal Model:Male Sprague Dawley rats (8 weeks of age) with myocardial I/R injury[4]
Dosage:2.5 μg/kg, 10 μg/kg, 25 μg/kg, 50 μg/kg, 100 μg/kg, and 250 μg/kg
Administration:Intravenous injection
Result:Immediately before or during ischemia reduced myocardial necrosis following I/R in the intact rat heart.
IC 50PAR1: 70 nM (IC50); PAR1: 35 nM (Ki)
N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride Preparation Products And Raw materials
Tag:N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride(245520-69-8) Related Product Information
Dimethylamine hydrochloride HEMATOPORPHYRIN DIHYDROCHLORIDE 7H-PYRROLO[3,2-F]QUINAZOLINE-1,3-DIAMINE N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride NA 7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2)