| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
|
| | Hematoporphyrin dihydrochloride Basic information |
| Product Name: | Hematoporphyrin dihydrochloride | | Synonyms: | 21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;21h,23h-porphine-2,18-propanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionicacid;acido1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionicodiclor;ematoporfirina;HEMATOPORPHYRIN IX DIHYDROCHLORIDE;HAEMATOPORPHYRIN DIHYDROCHLORIDE;8,13-BIS(1-HYDROXYETHYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID DIHYDROCHLORIDE | | CAS: | 17696-69-4 | | MF: | C34H39ClN4O6 | | MW: | 635.16 | | EINECS: | 241-699-4 | | Product Categories: | Natural Porphyrins and Derivitives;Porphyrins;Biochemistry;Miscellaneous Biochemicals;porphine (porphyrin) ligand | | Mol File: | 17696-69-4.mol |  |
| | Hematoporphyrin dihydrochloride Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | Very Dark Red | | Water Solubility | Insoluble in water. Soluble in pyridine (5%). | | Merck | 14,4636 | | BRN | 78957 | | Stability: | Hygroscopic | | EPA Substance Registry System | 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-, dihydrochloride (17696-69-4) |
| Risk Statements | 33 | | RTECS | TS5505000 | | TSCA | TSCA listed | | Toxicity | mouse,LD50,intraperitoneal,169mg/kg (169mg/kg),BEHAVIORAL: TREMORBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Bollettino Chimico Farmaceutico. Vol. 117, Pg. 145, 1978. |
| Provider | Language |
|
ALFA
| English |
| | Hematoporphyrin dihydrochloride Usage And Synthesis |
| Description | Hematoporphyrin is a photosensitizer. Hematoporphyrin (3 μM) increases oxygen consumption and decreases the respiratory control ratio (RCR) in irradiated isolated rat liver mitochondria. It induces DNA breaks in cell-free assays, but not in human HeLa cervical cancer cells, in a light-dependent manner when used at a concentration of 6 μM. Hematoporphyrin (12 μM) decreases the survival of irradiated, but not non-irradiated, HeLa cells. Hematoporphyrin (5 mg/kg) decreases growth of subcutaneous Yoshida AH-130 hepatoma tumors in rats when administered with radiation. | | Uses | Endogenous porphyrin formed by the acid hydrolysis of hemoglobin. It is employed as an active pharmaceutical intermediate. | | References | [1] KESSEL D. Hematoporphyrin and HPD: photophysics, photochemistry and phototherapy.[J]. Photochemistry and Photobiology, 1984, 39 6: 851-859. DOI: 10.1111/j.1751-1097.1984.tb08871.x
[2] C SALET G M. Photodynamic effects of haematoporphyrin on respiration and calcium uptake in isolated mitochondria.[J]. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1981, 39 2: 227-230. DOI: 10.1080/09553008114550261
[3] M. EGYEKI . DNA damaging capability of hematoporphyrin towards DNAs of various accessibilities[J]. Journal of photochemistry and photobiology. B, Biology, 2006, 84 2: Pages 119-127. DOI: 10.1016/j.jphotobiol.2006.02.005
[4] L TOMIO. Effect of hematoporphyrin and red light on AH-130 solid tumors in rats.[J]. Acta radiologica. Oncology, 1983, 22 1: 49-53. DOI: 10.3109/02841868309134338 |
| | Hematoporphyrin dihydrochloride Preparation Products And Raw materials |
|