- 5-Thio-D-glucose
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2026-09-11
- CAS:20408-97-3
- Min. Order: 10G
- Purity: 98%min
- Supply Ability: 30kg/month
- 5-THIO-D-GLUCOSE
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- $1.00
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2019-07-06
- CAS:20408-97-3
- Min. Order: 1G
- Purity: 98%
- Supply Ability: 100KG
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| | 5-THIO-D-GLUCOSE Basic information |
| Product Name: | 5-THIO-D-GLUCOSE | | Synonyms: | 5-Thio-α-D-glucopyranose;α-D-Glucothiopyranose;5-Thio-D-glucose,predominantly &-anomer;5-Thio-D-glucose, alpha-anomer;5-Thio-D-glucose ,98%;NSC 204984;5-Thio-D-glucose, ≥98.0% (HPLC);(2R,3R,4S,5R)-2,3,4,6-Tetrahydroxy-5-mercaptohexanal | | CAS: | 20408-97-3 | | MF: | C6H12O5S | | MW: | 196.22 | | EINECS: | 243-798-8 | | Product Categories: | 13C & 2H Sugars;Carbohydrates & Derivatives;Sulfur & Selenium Compounds;Biochemicals and Reagents;Carbohydrates;Monosaccharide | | Mol File: | 20408-97-3.mol |  |
| | 5-THIO-D-GLUCOSE Chemical Properties |
| Melting point | 135-138 °C(lit.) | | Boiling point | 303.11°C (rough estimate) | | density | 1.271 (estimate) | | refractive index | 1.5060 (estimate) | | storage temp. | 2-8°C | | solubility | Soluble in Water (up to 15 mg/ml) | | form | Powder | | pka | 9.11±0.10(Predicted) | | color | White | | Optical Rotation | [α]/D 220.0±5.0°, c = 1 in 0.1 M HCl | | Water Solubility | Miscible with water. | | Merck | 13,9408 | | BRN | 1865193 | | Stability: | Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months. | | InChI | 1S/C6H12O5S/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1 | | InChIKey | KNWYARBAEIMVMZ-DVKNGEFBSA-N | | SMILES | OC[C@H]1S[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O | | CAS DataBase Reference | 20408-97-3 | | EPA Substance Registry System | D-Glucose, 5-thio- (20408-97-3) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | LZ7500000 | | F | 3-10-23 | | Storage Class | 11 - Combustible Solids | | Toxicity | mouse,LD50,intraperitoneal,5500mg/kg (5500mg/kg),International Journal of Radiation Oncology, Biology, Physics. Vol. 8, Pg. 589, 1982. |
| | 5-THIO-D-GLUCOSE Usage And Synthesis |
| Description | 5-Thio-D-glucose (20408-97-3) is a potent competitive inhibitor of the cellular transport of glucose and glucose-mediated insulin release.1 May be used to induce a state of glucose deprivation in laboratory animals.2 Stimulates feeding in rat models.3 Induces Alzheimer-like changes in frontal cortex and hippocampus in rats.4 Elevates renal TGF-b1 at a dose that does not prevent streptozotocin diabetes in rats.5 | | Uses | 5-Thio-D-glucose (cas# 20408-97-3) is a compound useful in organic synthesis. | | References | [1] Z WANG H G. Glucose transporter 2 expression: prevention of streptozotocin-induced reduction in beta-cells with 5-thio-D-glucose.[J]. Experimental and Clinical Endocrinology & Diabetes, 1995, 103 Suppl 2: 83-97. DOI:10.1055/s-0029-1211400
[2] MAITREYEE SHAH. Recurrent glucose deprivation leads to the preferential use of lactate by neurons in the ventromedial hypothalamus.[J]. American journal of physiology. Endocrinology and metabolism, 2019, 316 5: E948-E955. DOI:10.1152/ajpendo.00468.2018
[3] AI-JUN LI. Stimulation of feeding by three different glucose-sensing mechanisms requires hindbrain catecholamine neurons.[J]. American journal of physiology. Regulatory, integrative and comparative physiology, 2014, 306 4: R257-64. DOI:10.1152/ajpregu.00451.2013
[4] MELITA SALKOVIC-PETRISIC. Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway[J]. Journal of Neurochemistry, 2006, 96 4: 1005-1015. DOI:10.1111/j.1471-4159.2005.03637.x
[5] LANE P. 5-thio-D-glucose elevates renal transforming growth factor beta-1 at a dose that does not prevent streptozocine diabetes in rats.[J]. Endocrinology, 2000, 26 1: 3337-3342. DOI:10.1210/en.141.9.3337 |
| | 5-THIO-D-GLUCOSE Preparation Products And Raw materials |
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