- SCH-202676 HBr
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- $1980.00
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2026-07-27
- CAS:70375-43-8
- Purity:
- Supply Ability: 10g
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| | N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide Basic information |
| Product Name: | N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide | | Synonyms: | AURORA KA-7903;N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5-(2H)-YLIDENE)METHANAMINE, HBR;SCH-202676;SCH 202676 HYDROBROMIDE;Methanamine, N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-;SCH 202676 HBr;SCH202676 HBr;SCH-202676 HBr | | CAS: | 70375-43-8 | | MF: | C15H13N3S | | MW: | 267.35 | | EINECS: | | | Product Categories: | G-Protein | | Mol File: | 70375-43-8.mol |  |
| | N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide Chemical Properties |
| Melting point | 240.0-240.8 °C(lit.) | | storage temp. | Desiccate at +4°C | | solubility | DMSO: 40 mg/mL | | form | Yellow solid. | | color | Beige | | Stability: | Stable for 1 year from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide Usage And Synthesis |
| Description | SCH-202676 (70375-43-8) is a reversible inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs).1 IC50‘s = 0.1-1.7 μM for nine GPCRs.1 Modification of GPCRs is accomplished via sulfhydryl modification.2,3 | | Uses | SCH-202676 hydrobromide is a modulator that inhibits binding to G protein-coupled receptors. | | Biological Activity | Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC 50 values are 0.1-1.8 μ M). | | IC 50 | Adenosine A3 receptor | | References | [1] A B FAWZI. SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors.[J]. Molecular Pharmacology, 2001, 59 1: 30-37. DOI:10.1124/mol.59.1.30
[2] ANNA M LEWANDOWICZ Jarmo T L Jouko Vepsäläinen. The “allosteric modulator” SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms.[J]. British Journal of Pharmacology, 2006, 147 4: 422-429. DOI:10.1038/sj.bjp.0706624
[3] ANIKÓ GÖBLYÖS. Synthesis and Biological Evaluation of a New Series of 2,3,5-Substituted [1,2,4]-Thiadiazoles as Modulators of Adenosine A1 Receptors and Their Molecular Mechanism of Action[J]. Journal of Medicinal Chemistry, 2005, 48 4: 1145-1151. DOI:10.1021/jm049337s |
| | N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide Preparation Products And Raw materials |
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