- MK 571
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- $48.00
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2026-07-15
- CAS:115104-28-4
- Purity: 98.32%
- Supply Ability: 10g
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| | (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Basic information |
| | (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Chemical Properties |
| Melting point | 65-70°C | | Boiling point | 712.3±60.0 °C(Predicted) | | density | 1.327±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO (up to 50 mg/ml). | | pka | 4.27±0.10(Predicted) | | form | Off-white solid. | | color | Yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. | | InChIKey | AXUZQJFHDNNPFG-UXBLZVDNSA-N | | SMILES | S(C(SCCC(=O)O)c1cc(ccc1)\C=C\c2nc3c(cc2)ccc(c3)Cl)CCC(=O)N(C)C |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Usage And Synthesis |
| Description | MK-571 is a selective, orally active CysLT1 receptor antagonist. It blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively, which is indicative of CysLT1 receptor-mediated activity in these preparations. MK-571 effectively blocks LTD4 activation of recombinant human and murine CysLT1 receptors but is ineffective at blocking LTC4 or LTD4 activation of the recombinant human or murine CysLT2 receptors. | | Chemical Properties | Yellow Solid | | Uses | A receptor antagonist for the treatment of respiratory diseases. Cysteinyl leukotriene receptor antagonist MK-571 alters bronchoalveolar lavage fluid proteome in asthma. | | Definition | ChEBI: MK 571 is a member of quinolines. | | Biological Activity | Potent CysLT 1 (LTD 4 ) leukotriene receptor inverse agonist (EC 50 = 1.3 nM). Antagonizes LTD 4 -induced contractions of guinea pig trachea and ileum (pA 2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells. | | storage | Store at -20°C | | References | [1] T R JONES. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist.[J]. Canadian journal of physiology and pharmacology, 1989, 67 1: 17-28. DOI:10.1139/y89-004
[2] DENIS J DUPRÉ. Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.[J]. Journal of Pharmacology and Experimental Therapeutics, 2004, 309 1: 102-108. DOI:10.1124/jpet.103.059824
[3] E VELLENGA. Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1.[J]. British Journal of Pharmacology, 1999, 127 2: 441-448. DOI:10.1038/sj.bjp.0702577 |
| | (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Preparation Products And Raw materials |
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