| Company Name: |
TCI Europe |
| Tel: |
320-37350700 |
| Email: |
sales@tcieurope.eu |
- 2,4-DPD
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- $29.00
-
2026-06-08
- CAS:41438-38-4
- Purity: 99.74%
- Supply Ability: 10g
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| | 2,4-Diethylpyridine dicarboxylate Basic information |
| Product Name: | 2,4-Diethylpyridine dicarboxylate | | Synonyms: | DIETHYL 2,4-PYRIDINECARBOXYLATE;Diethyl 2,4-pyridinedicarboxylate;2,4-Pyridinedicarboxylic acid, diethyl ester
Pyridine-2,4-Dicarboxylic Acid Diethyl Ester;2,4-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER;2,4-DPD;2,4-Pyridinedicarboxylic;2,4-pyridinedicarboxylicacid,ethylester;diethyl 2,4-pyridinedicarboxylic acid | | CAS: | 41438-38-4 | | MF: | C11H13NO4 | | MW: | 223.23 | | EINECS: | 680-341-5 | | Product Categories: | Pyridines, Pyrimidines, Purines and Pteredines | | Mol File: | 41438-38-4.mol |  |
| | 2,4-Diethylpyridine dicarboxylate Chemical Properties |
| Melting point | 31 °C | | Boiling point | 330.9±22.0 °C(Predicted) | | density | 1.165±0.06 g/cm3(Predicted) | | vapor pressure | 0.022Pa at 25℃ | | storage temp. | 2-8°C | | solubility | ≤50mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide | | pka | -0.69±0.10(Predicted) | | form | Crystalline | | color | White to Almost white | | Cosmetics Ingredients Functions | SKIN CONDITIONING
HAIR CONDITIONING | | InChI | InChI=1S/C11H13NO4/c1-3-15-10(13)8-5-6-12-9(7-8)11(14)16-4-2/h5-7H,3-4H2,1-2H3 | | InChIKey | MUUDQLHCIAOWPR-UHFFFAOYSA-N | | SMILES | C1(C(OCC)=O)=NC=CC(C(OCC)=O)=C1 | | LogP | 1.92 at 20℃ and pH7.82 | | Surface tension | 56.3mN/m at 1g/L and 19.7℃ | | CAS DataBase Reference | 41438-38-4 |
| | 2,4-Diethylpyridine dicarboxylate Usage And Synthesis |
| Uses | Diethyl pyridine-2,4-dicarb is a potent prolyl 4-hydroxylase-directed proinhibitor. Diethyl pyridine-2,4-dicarb inhibits prolyl hydroxylation and procollagen processing in chick-embryo calvaria[1]. | | Biological Activity | 2,4-dpd is a cell permeable, competitive inhibitor of the oxygen-sensing enzyme hif-α prolyl hydroxylase (hif-ph) [1].hypoxia-inducible factor (hif) is a transcription factor with a key role in cellular responses to hypoxia in a variety of organisms. the hif system plays an important role in angiogenesis, erythropoiesis, energy utilization, glucose/energy metabolism, tumour development, and ischaemic/hypoxic disease. genetic or pharmacological inactivation of the hif hydroxylases results in a constitutive activation of the hif pathway with little or even absent regulation by oxygen remaining. the oxygen-sensing enzyme hif-α prolyl hydroxylase catalyzes hydroxylation of specific prolyl and asparaginyl residues in the regulatory hif-α subunits [2].exposure to 2,4-dpd limited prolyl 4-hydroxylase activity in c. elegans., where their esters are hydrolyzed to form competitors of a -ketoglutarate. 2,4-dpd showed dramatic effects among the progeny. when exposed to a high level of 2,4-dpd (2.7 mm), all progeny died regardless of genotype of c. elegans. the dead embryos arrested at the twofold stage [1]. | | references | [1] friedman l, higgin j j, moulder g, et al. prolyl 4-hydroxylase is required for viability and morphogenesis in caenorhabditis elegans[j]. proceedings of the national academy of sciences, 2000, 97(9): 4736-4741.
[2] schofield c j, ratcliffe p j. signalling hypoxia by hif hydroxylases[j]. biochemical and biophysical research communications, 2005, 338(1): 617-626. |
| | 2,4-Diethylpyridine dicarboxylate Preparation Products And Raw materials |
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