4-Methyl-pyridine-2-carboxylic acid

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4-Methyl-pyridine-2-carboxylic acid manufacturers

4-Methyl-pyridine-2-carboxylic acid Basic information

Product Name:	4-Methyl-pyridine-2-carboxylic acid
Synonyms:	4-Methylpyridine-2-carboxylic acid 97%;4-Methylpicolinic acid ,97%;4-Methylpyridine-2-carboxylic acid ,97%;4-Methylpicolinic acid, 2-Carboxy-4-methylpyridine;2-Pyridinecarboxylic acid, 4-methyl-;RARECHEM AL BO 2389;4-Methylpicolinicaci;4-Methy4-Methylpyridine-2-carboxylic acidlpyridine-2-carboxylic acid
CAS:	4021-08-3
MF:	C7H7NO2
MW:	137.14
EINECS:
Product Categories:	Carboxylic Acids;C7 and C8;Heterocyclic Building Blocks;Heterocyclic Compounds;pharmacetical;Pyridine series;Carboxylic Acids;Pyridines
Mol File:	4021-08-3.mol

4-Methyl-pyridine-2-carboxylic acid Chemical Properties

Melting point	137-141 °C
Boiling point	307.4±22.0 °C(Predicted)
density	1.230±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to crystal
pka	1.11±0.50(Predicted)
color	White to Light yellow
InChI	1S/C7H7NO2/c1-5-2-3-8-6(4-5)7(9)10/h2-4H,1H3,(H,9,10)
InChIKey	CMMURVLHXMNTHY-UHFFFAOYSA-N
SMILES	Cc1ccnc(c1)C(O)=O
CAS DataBase Reference	4021-08-3(CAS DataBase Reference)

Safety Information

MSDS Information

4-Methyl-pyridine-2-carboxylic acid Usage And Synthesis

Chemical Properties	White to light brown solid
Uses	4-Methylpyridine-2-carboxylic acid is a used in biological studies for the mutasynthesis of potential neuroprotectant derivatives of the bipyridyl collismycin A.
Synthesis	1620-76-4 4021-08-3 General procedure for the synthesis of 4-methylpyridine-2-carboxylic acid from 2-cyano-4-methylpyridine: 2-cyano-4-methylpyridine (0.15 g, 1.27 mmol) was dissolved in about 10 mL of 6 M hydrochloric acid and heated and refluxed for 24 hours. During the reaction, the solution gradually changed from the initial pale yellow color to clear. Upon completion of the reaction, the solution was evaporated to dryness to give a white solid product. Purification by recrystallization from a minimal amount of distilled water resulted in 148 mg (85% yield) of 4-methylpyridine-2-carboxylic acid. The product was characterized by 1H NMR (DMSO-d6): δ = 8.65 (1H, s), 8.06 (1H, s), 7.66 (1H, s), 2.05 (3H, s).
References	[1] Patent: WO2008/17855, 2008, A1. Location in patent: Page/Page column 49 [2] Patent: US5219847, 1993, A [3] Advanced Synthesis and Catalysis, 2013, vol. 355, # 5, p. 947 - 956 [4] Patent: US6251919, 2001, B1

4-Methyl-pyridine-2-carboxylic acid Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Hydrochloric acid-->Ethyl acetate-->Dichloromethane-->Acetic acid-->Petroleum ether-->Potassium carbonate-->Sodium sulfate-->Hydrogen peroxide-->Dimethyl sulfate-->POTASSIUM CYANIDE-->3-Chloroperoxybenzoic acid-->Dimethylcarbamoyl chloride-->Trimethylsilyl cyanide-->4-Methylpyridine
Preparation Products	Argatroban-->2-Bromo-4-methylpyridine-->2-Methylpropanedioic acid-->4-Bromo-N-methoxy-N-methylpicolinamide

Tag:4-Methyl-pyridine-2-carboxylic acid(4021-08-3) Related Product Information

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