Cyclic di-IMP (sodium salt) manufacturers
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| | Cyclic di-IMP (sodium salt) Basic information |
| | Cyclic di-IMP (sodium salt) Chemical Properties |
| solubility | Water: 50 mg/ml |
| | Cyclic di-IMP (sodium salt) Usage And Synthesis |
| Description | Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP (Item No. 17144) and cyclic di-AMP (Item No. 17753).1 C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) plus c-di-IMP through the intranasal route show a humoral immune response, evidenced by an increase in IgG titers up to 2-fold compared to mice immunized with β-gal alone. Mice immunized with β-gal plus c-di-IMP also exhibit a Th1/Th2 response, indicating that the adjuvant activity of c-di-IMP leads to a cellular immune response as well.WARNING This product is not for human or veterinary use. | | References | [1] RIMMA LIBANOVA . The member of the cyclic di-nucleotide family bis-(3′, 5′)-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant[J]. Vaccine, 2010, 28 10: Pages 2249-2258. DOI: 10.1016/j.vaccine.2009.12.045 |
| | Cyclic di-IMP (sodium salt) Preparation Products And Raw materials |
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