Cyclic di-GMP (sodium salt) manufacturers
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| | Cyclic di-GMP (sodium salt) Basic information |
| Product Name: | Cyclic di-GMP (sodium salt) | | Synonyms: | Cyclic di-GMP (sodium salt);Cyclic-di-GMP disodium;guanylyl-(3'→5')-3'-guanylicacid,cyclicnucleotide,disodiumsalt;Cyclic diguanylate|||5GP-5GP disodium|||3',5'-Cyclic diguanylic acid|||Cyclic di-GMP (sodium salt)|||cyclic diguanylate disodium|||c-di-GMP|||c-di-GMP disodium;3'-Guanylic acid,guanylyl-(3'→5')-,cyclic nucleotide,sodium salt;Cyclic di-GMP disodium salt | | CAS: | 2222132-40-1 | | MF: | C20H25N10NaO14P2 | | MW: | 714.41 | | EINECS: | | | Product Categories: | | | Mol File: | 2222132-40-1.mol |  |
| | Cyclic di-GMP (sodium salt) Chemical Properties |
| storage temp. | Store at -80°C, protect from light, stored under nitrogen | | solubility | Water: 1 mg/ml | | form | A crystalline solid | | color | Off-white to light yellow | | Water Solubility | Soluble to 20 mM in water |
| | Cyclic di-GMP (sodium salt) Usage And Synthesis |
| Description | Cyclic di-GMP sodium is a second messenger in bacteria involved in diverse prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling. | | Uses | Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research[1][2][3][4]. | | in vivo | Cyclic-di-GMP disodium (100 μg/per; i.v.; two sequential vaccinations 9 days apart) enhances TriVax-induced immune responses to melanoma in mice and further increased the anti-tumor effects of TriVax[3]. | Animal Model: | C57BL/6 (B6) mice (8- to 10-week-old)[3]. | | Dosage: | 100 μg/per | | Administration: | Intravenous injection; two sequential vaccinations 9 days apart; combine with TriVax. | | Result: | Significantly higher numbers of antigen-specific CD8 T cells when combined with TriVax. (TriVax consisted of a mixture of 120 μg Pam-hgp100, 100 μg hgp100 or 100 μg Ova, 50 or 25 μg anti-CD40 antibody, and 25 μg Poly-IC).
Enhanced the anti-tumor activity of TriVax.
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| | storage | Store at -20°C | | References | [1] Karaolis DK, et al. 3',5'-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation. Biochem Biophys Res Commun. 2005 Apr 1;329(1):40-5. DOI:10.1016/j.bbrc.2005.01.093
[2] Steinberger O, et al. Elevated expression of the CD4 receptor and cell cycle arrest are induced in Jurkat cells by treatment with the novel cyclic dinucleotide 3',5'-cyclic diguanylic acid. FEBS Lett. 1999 Feb 5;444(1):125-9. DOI:10.1016/s0014-5793(99)00036-8
[3] Wang Z, et al. STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice. Cancer Immunol Immunother. 2015 Aug;64(8):1057-66. DOI:10.1007/s00262-015-1713-5
[4] Jenal U, et al. Cyclic di-GMP: second messenger extraordinaire. Nat Rev Microbiol. 2017 May;15(5):271-284. DOI:10.1038/nrmicro.2016.190 |
| | Cyclic di-GMP (sodium salt) Preparation Products And Raw materials |
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