| Company Name: |
Nanjing Dulai Biotechnology Co., Ltd.
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| Tel: |
025-84699383-8003;025-846993838003-8003 18013301593;18013301590 |
| Email: |
njduly@126.com |
| Products Intro: |
Product Name:PF 6274484
CAS:1035638-91-5
Purity:>=98%(HPLC) Package:250mg
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PF-6274484 manufacturers
- PF-6274484
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- $34.00 / 2mg
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2026-04-20
- CAS:1035638-91-5
- Min. Order:
- Purity: 99.12%
- Supply Ability: 10g
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| | PF-6274484 Basic information |
| Product Name: | PF-6274484 | | Synonyms: | PF-6274484;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide;2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-;PF-6274484 >=98% (HPLC);oxidation,autophosphorylation,PF6274484,PF-6274484,EGFR,signaling,Epidermal growth factor receptor,HER1,protein,ErbB-1,inhibit,kinase,cysteine,Inhibitor;N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)acrylamide;PF-6274484, 10 mM in DMSO | | CAS: | 1035638-91-5 | | MF: | C18H14ClFN4O2 | | MW: | 372.78 | | EINECS: | | | Product Categories: | | | Mol File: | 1035638-91-5.mol |  |
| | PF-6274484 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 33 mg/ml; DMSO: 25 mg/ml | | form | A crystalline solid | | color | Light yellow to orange | | InChI | 1S/C19H16ClFN4O/c1-4-11(2)24-17-8-13-16(9-18(17)26-3)22-10-23-19(13)25-12-5-6-15(21)14(20)7-12/h4-10,24H,1-2H2,3H3,(H,22,23,25) | | InChIKey | DTMQCGFVWWBONL-UHFFFAOYSA-N | | SMILES | FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OC)=C(NC(C=C)=O)C=C32 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | PF-6274484 Usage And Synthesis |
| Description | PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively. | | Uses | PF-6274484 is a potent EGFR inhibitor with Kis of 0.14 nM and 0.18 nM for EGFR-L858R/T790M and WT EGFR, respectively. PF-6274484 inhibits EGFR-L858R/T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC50s of 6.6 and 5.8 nM, respectively[1]. | | IC 50 | EGFR (WT): 0.18 nM (Ki); EGFRL858R/T790M: 0.14 nM (Ki) | | References | [1] Schwartz PA, et al. Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance. Proc Natl Acad Sci U S A. 2014;111(1):173-178. DOI:10.1073/pnas.1313733111 |
| | PF-6274484 Preparation Products And Raw materials |
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