- PF-04979064
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- $31.00
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2026-07-27
- CAS:1220699-06-8
- Purity: 99.98%
- Supply Ability: 10g
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| | PF-04979064 Basic information |
| Product Name: | PF-04979064 | | Synonyms: | PF-04979064;(S)-1-(1-(2-hydroxypropanoyl)piperidin-4-yl)-3-methyl-8-(6-methylpyridin-3-yl)-1H-imidazo[4,5-c][1,5]naphthyridin-2(3H)-one;CS-2664;PF-04979064 ≥95%;PF 04979064;PF04979064;2H-Imidazo[4,5-c][1,5]naphthyridin-2-one, 1,3-dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-;PF-04979064 >=98% (HPLC);1,3-Dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-2H-imidazo[4,5-c][1,5]naphthyridin-2-one | | CAS: | 1220699-06-8 | | MF: | C24H26N6O3 | | MW: | 446.5 | | EINECS: | | | Product Categories: | | | Mol File: | 1220699-06-8.mol |  |
| | PF-04979064 Chemical Properties |
| Boiling point | 682.0±55.0 °C(Predicted) | | density | 1.355±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 11 mg/mL (24.64 mM) | | form | Solid | | pka | 13.95±0.20(Predicted) | | color | White to yellow | | InChIKey | GACQNUHFDBEIQH-HNNXBMFYSA-N | | SMILES | CN(C(N1C2CCN(C([C@@H](O)C)=O)CC2)=O)C3=C1C4=NC(C5=CN=C(C)C=C5)=CC=C4N=C3 |
| WGK Germany | WGK 3 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral |
| | PF-04979064 Usage And Synthesis |
| Uses | PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively. | | Biological Activity | PF-04979064 is an orally available, potent and selective PI3K/mTOR dual kinase inhibitor th at potently inhibits tumor growth in mouse xenografts. | | in vivo | PF-04979064 is progressed to rat in vivo PK studies and exhibits robust PK profile: Vdss=5.23 L/kg, Cl=19.3 mL/min/kg, T1/2=1.85 h, and F%=61%[1]. | | IC 50 | PI3Kα: 0.13 nM (Ki); PI3Kγ: 0.111 nM (Ki); PI3Kδ: 0.122 nM (Ki); mTOR: 1.42 nM (Ki) | | References | [1] Cheng H et al. Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design. ACS Med Chem Lett, 2012 Nov 7, 4(1):91-7. DOI:10.1021/ml300309h |
| | PF-04979064 Preparation Products And Raw materials |
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