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BOC Sciences |
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1-631-485-4226; 16314854226 |
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PF 03463275 manufacturers
- PF-03463275
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- $51.00
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2026-05-06
- CAS:1173239-39-8
- Purity: 99.95%
- Supply Ability: 10g
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| | PF 03463275 Basic information |
| Product Name: | PF 03463275 | | Synonyms: | PF0346275;1H-Imidazole-4-carboxamide, N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1α,5α,6α)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl]methyl]-;PF-03463275, 10 mM in DMSO;1H-Imidazole-4-carboxamide, N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1α,5α,6α)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl]methyl]- | | CAS: | 1173239-39-8 | | MF: | C19H22ClFN4O | | MW: | 376.86 | | EINECS: | | | Product Categories: | | | Mol File: | 1173239-39-8.mol |  |
| | PF 03463275 Chemical Properties |
| Melting point | 125 °C | | Boiling point | 575.8±45.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 33.33 mg/mL (88.44 mM) | | pka | 10.07±0.40(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | PF 03463275 Usage And Synthesis |
| Uses | PF-03463275 is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a Ki of 11.6 nM. PF-03463275 has the potential for Schizophrenia research[1][2]. | | in vivo | PF-03463275 (1-10 mg/kg; s.c.) attenuates oscillatory potentials (OPs)[2]. | Animal Model: | Male Sprague-Dawley rats[2] | | Dosage: | 1, 3 and 10 mg/kg | | Administration: | S.c. | | Result: | A dose-dependent reduction in the amplitude of oscillatory potentials (OPs) elicited from the dark-adapted rats.
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| | IC 50 | GlyT1 | | References | [1] Lowe JA 3rd, et al. The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter [published correction appears in Bioorg Med Chem Lett. 2009 Aug 15;19(16):4885. Bronk, Brian S [added]; Schaeffer, Eric [added]]. Bioorg Med Chem Lett. 2009;19(11):2974-2976. DOI:10.1016/j.bmcl.2009.04.035
[2] Liu CN, Pettersen B, Seitis G, Osgood S, Somps C. GlyT1 inhibitor reduces oscillatory potentials of the electroretinogram in rats. Cutan Ocul Toxicol. 2014;33(3):206-211. DOI:10.3109/15569527.2013.833937 |
| | PF 03463275 Preparation Products And Raw materials |
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