| Company Name: |
Cool Pharm, Ltd |
| Tel: |
021-58581007 18019463053 |
| Email: |
sales@coolpharm.com |
TES-1025 manufacturers
- TES-1025
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- $35.00
-
2026-07-14
- CAS:1883602-21-8
- Purity: 98.81%
- Supply Ability: 10g
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| | TES-1025 Basic information |
| Product Name: | TES-1025 | | Synonyms: | 2-(3-(((5-cyano-6-oxo-4-(thiophen-2-yl)-1,6-dihydropyrimidin-2-yl)thio)methyl)phenyl)acetic acid;TES-1025;Benzeneacetic acid, 3-[[[5-cyano-1,6-dihydro-6-oxo-4-(2-thienyl)-2-pyrimidinyl]thio]methyl]-;inhibit,Inhibitor,TES 1025,TES1025,TES-1025;3-[[[5-cyano-1,6-dihydro-6-oxo-4-(2-thienyl)-2-pyrimidinyl]thio]methyl]phenylacetic acid;TES-1025 (TES1025) | | CAS: | 1883602-21-8 | | MF: | C18H13N3O3S2 | | MW: | 383.44 | | EINECS: | | | Product Categories: | | | Mol File: | 1883602-21-8.mol |  |
| | TES-1025 Chemical Properties |
| Boiling point | 602.4±65.0 °C(Predicted) | | density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (260.80 mM) | | form | Solid | | pka | 4.23±0.10(Predicted) | | color | White to yellow |
| | TES-1025 Usage And Synthesis |
| Uses | TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13 nM[1]. | | in vivo | TES-1025 is subjected to in vivo pharmacokinetic studies, following intravenous (IV) and oral (PO) dosings of male CD-1 mice. After the intravenous administration of 0.5 mg/kg, TES-1025 shows low blood clearance, with low volumes of distribution and half-lives (t1/2) of about 5.33 h, although after oral administration at 5 mg/kg, the blood concentration of TES-1025 is quantifiable for up to 8 h. A good systemic exposure is recorded for TES-1025, with a Cmax of 2570 ng/mL reaches at 2 h after dosing. The greater oral exposure of TES-1025 is further confirmed in the liver and kidneys with AUC0-8h of 19 200 h ng/mL and 36 600 h ng/mL, respectively[1]. | | References | [1] Pellicciari R, et al. α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis. J Med Chem. 2018 Feb 8;61(3):745-759. DOI:10.1021/acs.jmedchem.7b01254 |
| | TES-1025 Preparation Products And Raw materials |
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