3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

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3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide manufacturers

  • Ro 61-8048
  • Ro 61-8048 pictures
  • $33.00
  • 2026-07-20
  • CAS:199666-03-0
  • Purity: 99.87%
  • Supply Ability: 10g
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Basic information
Product Name:3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
Synonyms:Ro 61-8048, >=98%;RO61-80483,4-dimethoxy-N-(4-(3-nitrophenyl)thiazol-2-yl)Benzenesulfonamide;3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide RO61-8048;RO 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide;KMO Inhibitor I, Ro 61-8048;3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide;3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide;3,4-diMethoxy-N-(4-(3-nitrophenyl)thiazol-2-yl)benzenesulfonaMide
CAS:199666-03-0
MF:C17H15N3O6S2
MW:421.45
EINECS:
Product Categories:Inhibitors
Mol File:199666-03-0.mol
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Structure
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Chemical Properties
Melting point 185℃
Boiling point 627.4±65.0 °C(Predicted)
density 1.471±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 2-8°C
solubility DMSO: ≥15mg/mL
pka6.29±0.10(Predicted)
form Yellow solid
color faint yellow to yellow
InChI1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19)
InChIKeyNDPBMCKQJOZAQX-UHFFFAOYSA-N
SMILESCOc1ccc(cc1OC)S(=O)(=O)Nc2nc(cs2)-c3cccc(c3)[N+]([O-])=O
Safety Information
Hazard Codes T
Risk Statements 25-36
Safety Statements 26-45
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Usage And Synthesis
UsesRo 61-8048 is a potent and competitive kynurenine 3-monooxygenase (KMO) inhibitor.
DefinitionChEBI: Ro 61-8048 is a C-nitro compound.
Biological ActivityPotent and competitive kynurenine 3-hydroxylase inhibitor (K i = 4.8 nM, IC 50 = 37 nM). Increases kynurenic acid levels to concentrations that antagonize the glycine site of NMDA receptors. Brain penetrant and exhibits antidystonic, anticonvulsant and neuroprotective activities.
Biochem/physiol ActionsRo 61-8048 is an inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain.
storage+4°C
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Preparation Products And Raw materials
Tag:3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide(199666-03-0) Related Product Information
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