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| | 3-METHOXY-BENZENE-1,2-DIAMINE Basic information |
| Product Name: | 3-METHOXY-BENZENE-1,2-DIAMINE | | Synonyms: | 3-Methoxyphenylene-1,2-diamine;hydrosulphate;2,3-Diaminoanisole;1,2-Diamino-3-methoxybenzene;3-Methoxy-1,2-phenylenediamine;3-METHOXY-BENZENE-1,2-DIAMINE;Esomeprazole Impurity 29;1,2-BenzenediaMine, 3-Methoxy- | | CAS: | 37466-89-0 | | MF: | C7H10N2O | | MW: | 138.17 | | EINECS: | | | Product Categories: | | | Mol File: | 37466-89-0.mol |  |
| | 3-METHOXY-BENZENE-1,2-DIAMINE Chemical Properties |
| Melting point | 77-78℃ | | Boiling point | 114-116 °C(Press: 0.5 Torr) | | density | 1.170±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 4.10±0.10(Predicted) | | form | solid | | color | Black | | Water Solubility | Slightly soluble in water. | | Sensitive | Air Sensitive | | CAS DataBase Reference | 37466-89-0 |
| HazardClass | 6.1 | | HS Code | 2922290090 |
| | 3-METHOXY-BENZENE-1,2-DIAMINE Usage And Synthesis |
| Uses | 3-Methoxy-o-phenylenediamine is used as pharmaceutical intermediate. | | Synthesis | General procedure for the synthesis of 1,2-diamino-3-methoxybenzene from 2-nitro-3-methoxyaniline: 5% palladium-carbon catalyst (18 mg, 20 wt%) was added to a solution of 2-nitro-3-methoxyaniline (90 mg, 0.54 mmol) in ethanol (3 mL). The reaction mixture was stirred at room temperature in a hydrogen atmosphere for 18 hours. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was subsequently evaporated to afford the target product 3-methoxy-1,2-benzenediamine (73 mg, 100% yield). | | References | [1] Patent: WO2006/50506, 2006, A1. Location in patent: Page/Page column 126
[2] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 11, p. 3441 - 3444
[3] Patent: EP2168959, 2010, A1. Location in patent: Page/Page column 121
[4] Patent: EP2168960, 2010, A1. Location in patent: Page/Page column 61-62
[5] Patent: US2011/301170, 2011, A1. Location in patent: Page/Page column 29 |
| | 3-METHOXY-BENZENE-1,2-DIAMINE Preparation Products And Raw materials |
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