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GeneTex, Inc. |
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international@genetex.com |
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Enzo Biochem Inc |
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Enzo Biochem Inc. 13797054060 |
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Biosynth Ltd |
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Abmart Inc |
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| | MBTPS2 ANTIBODY Chemical Properties |
| | MBTPS2 ANTIBODY Usage And Synthesis |
| Source | Rabbit | | Reactivity | Mouse | | Background | Membrane-bound transcription factor protease site 2, also known as site-2 protease, is a zinc metalloprotease in the Golgi membrane. It regulates cholesterol metabolism and unfolded protein response. When cells are deprived of cholesterol, sterol regulatory element-binding proteins move from the endoplasmic reticulum to the Golgi apparatus and are cleaved by site-1 protease and site-2 protease sequentially to release the active amino-terminal domains. These amino-terminal domains of SREBPs then translocate into the nucleus to induce expression of genes for cholesterol biosynthesis. During UPR, activating transcription factor 6 transports from ER to Golgi apparatus and is cleaved by S1P and S2P to release a cytosolic fragment. This cytosolic fragment relocates to the nucleus and activates the UPR gene expression. | | References | [1] Rawson, R.B. et al. (1997) Mol. Cell 1, 47-57.
[2] Zelenski, N.G. et al. (1999) J. Biol. Chem. 274, 21973-21980.
[3] Shen, J. and Prywes, R. (2004) J. Biol. Chem. 279, 43046-43051.
[4] Lee, K. et al. (2002) Genes Dev. 16, 452-466.
[5] DeBose-Boyd, R.A. et al. (1999) Cell 99, 703-712.
[6] Brown, M.S. and Goldstein, J.L. (1999) Proc. Natl. Acad. Sci. USA 96, 11041-11048.
[7] Kaufman, R.J. et al. (2002) Nat. Rev. Mol. Cell Biol. 3, 411-421. |
| | MBTPS2 ANTIBODY Preparation Products And Raw materials |
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