| Company Name: |
Daicel Chiral Technologies (China)CO.,LTD
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| Tel: |
021-50460086-9 15921403865 |
| Email: |
han_yajun@dctc.daicel.com |
| Products Intro: |
Product Name:Thalidomide-4-amido-C1-PEG3-NH2 HCl
CAS:2380273-75-4
Purity:待询 Package:待询 Remarks:212169(Component:2380273-74-3)
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Pomalidomide-PEG3-NH2 hydrochloride
Purity:>=95% Package:50MG Remarks:901495-50MG
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Pomalidomide-PEG3-NH2 hydrochloride manufacturers
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| | Pomalidomide-PEG3-NH2 hydrochloride Basic information |
| Product Name: | Pomalidomide-PEG3-NH2 hydrochloride | | Synonyms: | Pomalidomide-PEG3-NH2 hydrochloride;2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide hydrochloride;P933620 Pomalidomide-amino-PEG3-NH2 hydrochloride;HCl NH2-PEG3-CH2CO-Poma;Thalidomide-4-amido-C1-PEG3-NH2 HCl | | CAS: | 2380273-75-4 | | MF: | C21H27ClN4O8 | | MW: | 498.92 | | EINECS: | | | Product Categories: | | | Mol File: | 2380273-75-4.mol |  |
| | Pomalidomide-PEG3-NH2 hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | form | Solid | | color | White to off-white |
| | Pomalidomide-PEG3-NH2 hydrochloride Usage And Synthesis |
| Uses | Protein degrader builiding block Pomalidomide-PEG3-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. | | reaction suitability | reactivity: carboxyl reactive
reagent type: ligand-linker conjugate | | IC 50 | Cereblon |
| | Pomalidomide-PEG3-NH2 hydrochloride Preparation Products And Raw materials |
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