Tauroursodeoxycholate dihydrate manufacturers
|
| | Tauroursodeoxycholate dihydrate Basic information |
| Product Name: | Tauroursodeoxycholate dihydrate | | Synonyms: | Tauroursodeoxycholate dihydrate;TAUROURSODEOXYCHOLATE DIHYDRATE (TUDCA DIHYDRATE; UR 906 DIHYDRATE; TAUROLITE DIHYDRATE);UR 906 dihydrate;2-((R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonic acid dihydrate;Tauroursodeoxycholate dihydrate (Standard);Taurolite dihydrate);Tauroursodeoxycholate dihydrate (TUDCA dihydrate;Tauroursodeoxycholic Acid Dihydrate in Methanol | | CAS: | 117609-50-4 | | MF: | C26H47NO7S | | MW: | 517.72 | | EINECS: | | | Product Categories: | | | Mol File: | 117609-50-4.mol |  |
| | Tauroursodeoxycholate dihydrate Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 83.33 mg/mL (155.54 mM) ,Water:12.5mg/mL(25.02 mM) | | form | Solid | | color | White to off-white | | InChIKey | XOSBJJOXVSXOFR-UWHYVWSJNA-N | | SMILES | C[C@]12CC[C@]3([H])[C@]4(CC[C@@H](O)C[C@@]4([H])C[C@H](O)[C@@]3([H])[C@]1([H])CC[C@]2([H])[C@H](C)CCC(=O)NCCS(O)(=O)=O)C.O |&1:1,4,6,9,12,15,17,19,23,25,r| |
| | Tauroursodeoxycholate dihydrate Usage And Synthesis |
| Uses | Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK[1][2]. | | IC 50 | Human Endogenous Metabolite | | References | [1] Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16. DOI:10.1093/cvr/cvr219
[2] Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345. DOI:10.1016/j.ejvs.2016.10.026 |
| | Tauroursodeoxycholate dihydrate Preparation Products And Raw materials |
|