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| | DBCO-PEG6-amine,DBCO-PEG6-NH2 Basic information |
| Product Name: | DBCO-PEG6-amine,DBCO-PEG6-NH2 | | Synonyms: | DBCO-PEG6-amine,DBCO-PEG6-NH2;DBCO-PEG6-amine TFA salt;Dibenz[b,f]azocine-5(6H)-butanamide, N-(20-amino-3,6,9,12,15,18-hexaoxaeicos-1-yl)-11,12-didehydro-γ-oxo-;DBCO-CONH-PEG6-CH2CH2NH2?TFA | | CAS: | 2353409-98-8 | | MF: | C33H45N3O8 | | MW: | 611.74 | | EINECS: | | | Product Categories: | | | Mol File: | 2353409-98-8.mol |  |
| | DBCO-PEG6-amine,DBCO-PEG6-NH2 Chemical Properties |
| Boiling point | 823.0±65.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 15.14±0.46(Predicted) | | form | Solid-Liquid Mixture | | color | White to off-white |
| | DBCO-PEG6-amine,DBCO-PEG6-NH2 Usage And Synthesis |
| Description | DBCO-PEG6-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound. | | Uses | DBCO-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG6-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | DBCO-PEG6-amine,DBCO-PEG6-NH2 Preparation Products And Raw materials |
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