DBCO-PEG2-amine

Request For Quotation
DBCO-PEG2-amine Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:DBCO-PEG2-amine
CAS:2250216-96-5
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: XIAMEN SINOPEG BIOTECH CO., LTD.
Tel: +86-0592-7761068 15616186207
Email: changaiwei@sinopeg.com
Products Intro: Product Name:DBCO-PEG2-NH2
CAS:2250216-96-5
Purity:98% Package:1g|10g|100g
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology
Tel: 18143011203
Email: info@chemextension.com
Products Intro: Product Name:DBCO-PEG2-amine TFA salt
CAS:2250216-96-5
Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing
Company Name: Aladdin Scientific
Tel:
Email: tp@aladdinsci.com
Products Intro: Product Name:DBCO-PEG2-amine TFA salt
CAS:2250216-96-5
Purity:98% Package:$1051.9/50mg;$1681.9/100mg;$2671.9/250mg;Bulk package Remarks:98%
Company Name: Shanghai Macklin Biochemical Co.,Ltd.  
Tel: 15221275939 15221275939
Email: shenlinxing@macklin.cn
Products Intro: Product Name:DBCO-PEG2-amine
CAS:2250216-96-5
Purity:>=95% Package:100mg；250mg；1g
DBCO-PEG2-amine Basic information
Product Name:DBCO-PEG2-amine
Synonyms:DBCO-PEG2-amine
CAS:2250216-96-5
MF:C25H29N3O4
MW:435.52
EINECS:
Product Categories:
Mol File:2250216-96-5.mol
DBCO-PEG2-amine Structure
DBCO-PEG2-amine Chemical Properties
Boiling point 748.9±60.0 °C(Predicted)
density 1.24±0.1 g/cm3(Predicted)
solubility Soluble in DMSO, DCM, DMF
pka15.14±0.46(Predicted)
InChIInChI=1S/C25H29N3O4/c26-13-15-31-17-18-32-16-14-27-24(29)11-12-25(30)28-19-22-7-2-1-5-20(22)9-10-21-6-3-4-8-23(21)28/h1-8H,11-19,26H2,(H,27,29)
InChIKeyILEXOUGGKQHBOX-UHFFFAOYSA-N
SMILESC(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)NCCOCCOCCN
Safety Information
MSDS Information
DBCO-PEG2-amine Usage And Synthesis
DescriptionDBCO-PEG2-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound.
UsesDBCO-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG2-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
DBCO-PEG2-amine Preparation Products And Raw materials
Tag:DBCO-PEG2-amine(2250216-96-5) Related Product Information
DBCO-PEG9-amine N-DBCO-N-bis(PEG2-acid) m-PEG4-DBCO DBCO-PEG6-amine,DBCO-PEG6-NH2 DBCO-PEG3-OH DBCO-PEG4-triethoxysilane Propanoic acid, 3-[2-[2-[[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester 4,7,10,13,16,19,22,25-Octaoxa-28-azadotricosanoic acid, 32-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-29,32-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester DBCO-C6-acid DBCO-PEG4-maleimide DBCO-PEG3-Mal 4,7,10-Trioxa-13-azaheptadecanoic acid, 17-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-14,17-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester DBCO-Acid DBCO-PEG1 DBCO-PEG4-biotin DBCO-NHCO-PEG2-Biotin Ambient temperature 1H-Pyrrole-1-propanamide, N-[2-[2-[3-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethyl]-2,5-dihydro-2,5-dioxo-