Tyrphostin AG1433 manufacturers
- Tyrphostin AG1433
-
- $59.00
-
2026-09-10
- CAS:168835-90-3
- Purity: 98.47%
- Supply Ability: 10g
- Tyrphostin AG1433
-
- $59.00
-
2026-07-27
- CAS:168835-90-3
- Purity: 98.47%
- Supply Ability: 10g
|
| | Tyrphostin AG1433 Basic information |
| Product Name: | Tyrphostin AG1433 | | Synonyms: | 1,2-Benzenediol, 4-(6,7-dimethyl-2-quinoxalinyl)-;cytotoxicity,PDGFRβ,Tyrphostin AG 1433,AG-1433,Tyrphostin AG1433,VEGFR,AG 1433,kinases,Vascular endothelial growth factor receptor,SU 1433,Tyrphostin AG-1433,Platelet-derived growth factor receptor,angiogenesis,tyrosine,inhibit,VEGFR-2,Inhibitor,ATM,PDGFR,SU-1433;Tyrphostin A 1433;Tyrphostin AG1433, 10 mM in DMSO;Tyrphostin AG1433 ，S0763 | | CAS: | 168835-90-3 | | MF: | C16H14N2O2 | | MW: | 266.29 | | EINECS: | | | Product Categories: | | | Mol File: | 168835-90-3.mol |  |
| | Tyrphostin AG1433 Chemical Properties |
| Melting point | 280-282 °C | | Boiling point | 490.9±45.0 °C(Predicted) | | density | 1.300±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 62.5 mg/mL (234.71 mM) | | pka | 8.32±0.20(Predicted) | | form | Solid | | color | Light yellow to khaki |
| | Tyrphostin AG1433 Usage And Synthesis |
| Uses | Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation[1][2][3][4]. | | Biological Activity | Tyrphostin AG1433 (SU1433) is a tyrosine kinase inhibitor. It is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50 of 5.0 μM and 9.3 μM, respectively. It prevents blood vessel formation. | | in vivo | Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day- old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets. | | target | | Flk-1 < span> 9.3 μM (IC 50 ) | PDGFRβ 5 μM (IC 50 ) | | | IC 50 | Flk-1: 9.3 μM (IC50); PDGFRβ: 5 μM (IC50) | | References | [1] Serban F, et al. Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA-induced cell death in glioblastoma. J Immunoassay Immunochem. 2017;38(1):21-33. DOI:10.1080/15321819.2016.1209217
[2] Strawn LM, et al. Flk-1 as a target for tumor growth inhibition. Cancer Res. 1996 Aug 1;56(15):3540-5. PMID:8758924
[3] Kim TS, et al. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech. 2010 Nov-Dec;3(11-12):752-62. DOI:10.1242/dmm.004689
[4] Kroll J, et al. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem. 1997 Dec 19;272(51):32521-7. DOI:10.1074/jbc.272.51.32521 |
| | Tyrphostin AG1433 Preparation Products And Raw materials |
|