- Tyrphostin 23
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- $53.00
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2026-08-08
- CAS:118409-57-7
- Purity: 99.70%
- Supply Ability: 10g
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| | AG 18 Chemical Properties |
| Melting point | 225°C | | Boiling point | 421.1±45.0 °C(Predicted) | | density | 1.428±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO, ethanol, or DMF | | form | Yellow solid | | pka | 7.26±0.18(Predicted) | | color | Yellow | | biological source | synthetic (organic) | | λmax | 464nm(DMSO)(lit.) | | Stability: | Store in refrigerator | | InChI | 1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H | | InChIKey | VTJXFTPMFYAJJU-UHFFFAOYSA-N | | SMILES | Oc1ccc(cc1O)\C=C(\C#N)C#N |
| WGK Germany | 3 | | HS Code | 2926.90.5050 | | Storage Class | 11 - Combustible Solids |
| | AG 18 Usage And Synthesis |
| Chemical Properties | Yellow Powder | | Uses | AG 18 inhibits EGFR with IC50 of 35 μM. | | Uses | A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM). | | Definition | ChEBI: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols. | | Biological Activity | Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling. | | Biochem/physiol Actions | Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,. | | Synthesis | Example 12 Preparation of 2-(3,4-dihydroxybenzylidene)malononitrile: A mixture of 3,4-bis(methoxymethoxy)benzaldehyde (1.0 mmol), malononitrile (1.0 mmol), and NaOH (2 mg) in 5 mL of methanol was stirred for 24 hours at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure, the residue was dissolved in ethyl acetate and filtered through a silica gel pad. The filtrate was concentrated under reduced pressure to give the condensation product 2-(3,4-bis(methoxymethoxy)benzylidene)malononitrile as a yellow solid in 94% yield. The structure of the product was confirmed by 1H-NMR (300 MHz, CDCl3) and 13C-NMR (75 MHz, CDCl3): 1H-NMR δ (ppm) 7.86 (s, 1H), 7.68 (s, 1H), 7.53 (d, J = 9 Hz, 1H), 7.29 (d, J = 9 Hz, 1H), 5.35 (s, 2H), 5.28 (s, 2H), 5.28 (s, 2H). 5.28 (s, 2H), 3.54 (s, 3H), 3.53 (s, 3H); 13C-NMR δ (ppm) 168.1, 167.6, 149.8, 147.9, 134.6, 127.7, 126.1, 121.0, 118.8, 116.8, 96.0, 95.5, 56.9, 56.8. | | References | [1] Patent: US2003/73712, 2003, A1 |
| | AG 18 Preparation Products And Raw materials |
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