C26 Sphingomyelin (d18:1/26:0)

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CAS:221097-57-0
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C26 Sphingomyelin (d18:1/26:0) Basic information
Product Name:C26 Sphingomyelin (d18:1/26:0)
Synonyms:C26 Sphingomyelin (d18:1/26:0);(7S)-4-hydroxy-7-[(1R,2E)-1-hydroxy-2-hexadecen-1-yl]-N,N,N-trimethyl-9-oxo-3,5-dioxa-8-aza-4-phosphatetratriacontan-1-aminium, 4-oxide, inner salt
CAS:221097-57-0
MF:C49H99N2O6P
MW:843.31
EINECS:
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Mol File:221097-57-0.mol
C26 Sphingomyelin (d18:1/26:0) Structure
C26 Sphingomyelin (d18:1/26:0) Chemical Properties
storage temp. Store at -20°C
form A crystalline solid
Safety Information
MSDS Information
C26 Sphingomyelin (d18:1/26:0) Usage And Synthesis
UsesC26 Sphingomyelin (d18:1/26:0)-d4 is deuterium labeled C26 Sphingomyelin (d18:1/26:0). C26 Sphingomyelin (d18:1/26:0) is a biochemical reagent.[1]
DefinitionChEBI: N-hexacosanoylsphingosine-1-phosphocholine is a sphingomyelin d18:1 in which the ceramide N-acyl group is specified as hexacosanoyl. It has a role as a mouse metabolite. It is a sphingomyelin 44:1 and a sphingomyelin d18:1. It is functionally related to a hexacosanoic acid.
Biological ActivityC26 Sphingomyelin is a sphingolipid that has been found in serum and cell or brain extracts.1,2,3 C26 sphingomyelin levels are increased in the serum of patients with hemophagocytic lymphohistiocytosis, an inflammatory condition characterized by excessive immune activation.3 C26 sphingomyelin has been used a component of monolayers to study the influence of sphingomyelin acyl chain length on sphingomyelin-sterol interactions.4 [Matreya, LLC.]
References1.Wang, J.-R., Zhang, H., Yau, L.D., et al.Improved sphingolipidomic approach based on ultra-high performance liquid chromatography and multiple mass spectrometries with application to cellular neurotoxicityAnal. Chem.86(12)5688-5696(2014) 2.Willmann, J., Mahlstedt, K., Leibfritz, D., et al.Characterization of sphingomyelins in lipid extracts using a HPLC-MS-offline-NMR methodAnal. Chem.79(11)4188-4191(2007) 3.Jenkins, R.W., Clarke, C.J., Lucas, J.T., Jr., et al.Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosisAm. J. Hematol.88(11)E265-E272(2013) 4.Li, X.M., Momsen, M.M., Brockman, H.L., et al.Sterol structure and sphingomyelin acyl chain length modulate lateral packing elasticity and detergent solubility in model membranesBiophys. J.85(6)3788-3801(2003)
C26 Sphingomyelin (d18:1/26:0) Preparation Products And Raw materials
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