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| | 3-Cyano-5-nitroindole Basic information |
| | 3-Cyano-5-nitroindole Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | Appearance | Yellow to brown Solid |
| | 3-Cyano-5-nitroindole Usage And Synthesis |
| Uses |
3-Cyano-5-nitroindole is mainly used in pharmaceutical synthesis and organic experiments.
| | Synthesis | GENERAL METHOD: A mixture of CuI (0.6 mmol), 5-nitroindole (0.5 mmol), and phenylacetonitrile (0.6 mmol) in DMF (3.0 mL) was placed in air and reacted with stirring for 34 h at 100 °C, followed by cooling to room temperature. Upon completion of the reaction, the reaction mixture was quenched with 10 mL of water followed by extraction with dichloromethane (DCM, 3 x 10 mL). The organic layers were combined, washed with saturated aqueous sodium chloride solution and dried with anhydrous magnesium sulfate (MgSO). Finally, the solution was concentrated under reduced pressure and purified by column chromatography to afford the target product 5-nitroindole-3-carbonitrile. | | References | [1] Tetrahedron, 2013, vol. 69, # 21, p. 4236 - 4240 |
| | 3-Cyano-5-nitroindole Preparation Products And Raw materials |
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