- Latrunculin A
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- $2357.00 / 1mg
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2025-08-21
- CAS:76343-93-6
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | LATRUNCULIN A Basic information |
| Product Name: | LATRUNCULIN A | | Synonyms: | [1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-HYDROXY-5,12-DIMETHYL-3-OXO-2,16-DIOXABICYCLO[13.3.1]NONADECA-4,8,10-TRIEN-17-YL)-2-THIAZOLIDINONE;LAT-A;LATRUNCULIN A;LATRUNCULIN A, LATRUNCULIA MAGNIFICA;LAT-A, [1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone;(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone;4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone;NSC 613011 | | CAS: | 76343-93-6 | | MF: | C22H31NO5S | | MW: | 421.55 | | EINECS: | | | Product Categories: | | | Mol File: | 76343-93-6.mol |  |
| | LATRUNCULIN A Chemical Properties |
| alpha | D24 +152° (c = 1.2 in chloroform) | | storage temp. | -20°C | | solubility | DMSO: soluble | | form | waxy solid | | color | yellow | | biological source | sea sponge | | Optical Rotation | +144.423 （CHCl3） | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| | LATRUNCULIN A Usage And Synthesis |
| Description | Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion). Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro (Kd = 0.2 μM) and in cells (0.5 μM, 30 min).{ Latrunculin A (1-10 μM) causes depolymerization of tumor cell cytoskeleton within ten minutes. Overnight treatment of cells with latrunculin A (10 μM) strongly suppresses actin synthesis. Prolonged cell treatment blocks dexamethasone-induced changes in actin cytoskeleton with no effect on cell viability. | | Uses | Latrunculin A has been used as medium supplementation for A549 cells to determine the internalization mechanism of CAV9 in A549 human lung carcinoma cells. | | Uses | Latrunculin A, Latrunculia magnifica is a stabilizer of monomeric G-actin and polymerization inhibitor. | | Definition | ChEBI: A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia myc
fijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes. | | General Description | Latrunculin A, a toxin extracted from the red sea sponge Latrunculia magnifica. It participates in vitro in the morphological alteration of the polymerization of pure actin. It forms a complex by binding with the nucleotide cleft of actin for actin filaments elongation. | | Biochem/physiol Actions | Latrunculin A inhibits actin polymerization by a different mechanism than cytochalasins. Latrunculin A disrupts microfilament-mediated processes. | | storage | -20°C | | References | [1] MARTINE COUÉ . Inhibition of actin polymerization by latrunculin A[J]. FEBS Letters, 1987, 213 2: Pages 316-318. DOI:10.1016/0014-5793(87)81513-2
[2] ILAN SPECTOR. Latrunculins—novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D[J]. Cytoskeleton, 1989, 13 3: 127-144. DOI:10.1002/cm.970130302
[3] JUSHUO WANG Joseph W S Jean M Sanger. Differential effects of latrunculin-A on myofibrils in cultures of skeletal muscle cells: Insights into mechanisms of myofibrillogenesis[J]. Cytoskeleton, 2005, 62 1: 35-47. DOI:10.1002/cm.20083
[4] FULVIO REGGIORI. The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae.[J]. Molecular Biology of the Cell, 2005, 16 12: 5843-5856. DOI:10.1091/mbc.e05-07-0629
[5] FARZAD ASADI Jim K Dorothy Michalski. A Genetic Screen for Fission Yeast Gene Deletion Mutants Exhibiting Hypersensitivity to Latrunculin A.[J]. G3 (Bethesda, Md.), 2016: 3399-3408. DOI:10.1534/g3.116.032664 |
| | LATRUNCULIN A Preparation Products And Raw materials |
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