|
|
| | Butyl chloroformate Basic information |
| | Butyl chloroformate Chemical Properties |
| Hazard Codes | T | | Risk Statements | 10-23-34 | | Safety Statements | 26-36-45 | | RIDADR | UN 2743 | | WGK Germany | 1 | | F | 10-19 | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | II | | HS Code | 29159020 |
| | Butyl chloroformate Usage And Synthesis |
| Chemical Properties | clear liquid | | Uses | Butyl Chloroformate is a reactant in the preparation of Lapatinib derivatives as HER1/HER2 targeting antitumor drugs. | | General Description | A colorless liquid. Flash point near 70°F. Very toxic by inhalation. Denser than water. Used to make other chemicals. | | Air & Water Reactions | Highly flammable. Decomposes exothermically in water to give hydrochloric acid and organic acids. | | Reactivity Profile | Butyl chloroformate is incompatible with bases (including amines), with water, with strong oxidizing agents, with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. | | Health Hazard | Inhalation of vapor irritates nose and throat and can cause delayed pulmonary edema. Liquid irritates eyes and causes severe skin burns and irreversible skin damage if allowed to remain. Can cause blindness. Ingestion causes burns of mouth and stomach. | | Flammability and Explosibility | Flammable | | Synthesis | The n-butyl chloroformate was prepared as follows: 1580g of n-butanol (M=74) was preheated to 100C, added from the upper inlet of the reaction distillation tower using a stratospheric pump, and fully contacted with the phosgene gas (0.5MPa, M=98.9) entering from the lower inlet in the reaction section, which was 100C. The liquid hydrogen chloride and the excess of hydrogen chloride were separated by deep condensation at -40C through a heat exchanger into the reaction distillation tower for reuse. The generated hydrogen chloride and excess phosgene enter the subsequent recovery unit through the top of the tower and are separated by deep condensation at -40C. The liquid phosgene passes through a heat exchanger into the reaction distillation tower for reuse, and the hydrogen chloride gas is passed into a 1.0 wt% NaOH aqueous solution for absorption. The n-butyl chloroformate as a single product stream passes through the tower kettle into the storage tank for subsequent use. The composition of the reaction solution was analyzed by gas chromatography, which showed that the conversion of butanol was >99.9% and the selectivity of chloroformate was >99.9%. |
| | Butyl chloroformate Preparation Products And Raw materials |
|