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| | Erythromycin ethylsuccinate Basic information |
| | Erythromycin ethylsuccinate Chemical Properties |
| Melting point | 219-224 C | | Boiling point | 778.19°C (rough estimate) | | density | 1.1417 (rough estimate) | | refractive index | 1.5280 (estimate) | | Fp | >110°(230°F) | | storage temp. | Sealed in dry,Room Temperature | | solubility | ethanol: soluble50mg/mL | | pka | 13.09±0.70(Predicted) | | form | solid | | color | white | | Water Solubility | Freely soluble in organic solvents, practically insoluble in water | | Stability: | Hygroscopic | | Major Application | pharmaceutical
pharmaceutical small molecule | | InChIKey | NSYZCCDSJNWWJL-UHFFFAOYSA-N | | SMILES | C1(OC(=O)CCC(OCC)=O)C(N(C)C)CC(C)OC1OC1C(CC(C(C(C(O)C(O)(C)C(CC)OC(=O)C(C)C(OC2OC(C)C(O)C(C)(OC)C2)C1C)C)=O)C)(O)C | | CAS DataBase Reference | 1264-62-6 |
| | Erythromycin ethylsuccinate Usage And Synthesis |
| Chemical Properties | Erythromycin ethylsuccinate is a white powder or crystals, odourless and tasteless. It is insoluble in water, slightly soluble in diethyl ether, and readily soluble in anhydrous ethanol, acetone or chloroform. | | Uses | A broad spectrum antibiotic commonly targeting bacteria responsible for respiratory tract infections | | Definition | ChEBI: Erythromycin ethylsuccinate is a erythromycin derivative that is erythromycin A in which the hydroxy group at position 3R is substituted by a (4-ethoxy-4-oxobutanoyl)oxy group. It is used for the treatment of a wide variety of bacterial infections. It is a succinate ester, a cyclic ketone, an erythromycin derivative and an ethyl ester. It is functionally related to an erythromycin A. | | Application | Erythromycin Ethylsuccinate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations[1][2][3] by various chromatography techniques. | | Brand name | E-Mycin (Pharmacia & Upjohn); E.E.S.
(Abbott); Eryped (Abbott); Pediamycin (Ross); Wyamycin
(Wyeth). | | General Description | Erythromycin ethylsuccinate (EES, Pediamycin, EryPed) isthe ethylsuccinate mixed ester of erythromycin in which the2＇-hydroxyl group of the desosamine is esterified. It isabsorbed as the ester and hydrolyzed slowly in the body toform erythromycin. It is somewhat acid labile, and itsabsorption is enhanced by the presence of food. The ester isinsoluble in water but soluble in alcohol and ether. | | References | [1] FAHIMEH KAMAREI . Development of a stability-indicating high performance liquid chromatography method for assay of erythromycin ethylsuccinate in powder for oral suspension dosage form[J]. Arabian Journal of Chemistry, 2014, 7 6: Pages 1079-1085. DOI:10.1016/j.arabjc.2011.01.004.
[2] B. LIAWRUANGRATH S. L. High performance thin layer chromatographic determination of erythromycin in pharmaceutical preparations[J]. Chromatographia, 2001, 54 5-6: 405-408. DOI:10.1007/BF02492693.
[3] JACQUELINE WARDROP . Determination of Erythromycin and Related Substances in Enteric‐Coated Tablet Formulations by Reversed‐Phase Liquid Chromatography[J]. Journal of pharmaceutical sciences, 2000, 89 9: Pages 1097-1105. DOI:10.1002/1520-6017(200009)89:9<1097::AID-JPS1>3.0.CO;2-D. |
| | Erythromycin ethylsuccinate Preparation Products And Raw materials |
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