| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
Ac-Trp-3,5-bis(trifluoromethyl)benzyl ester manufacturers
- L-732138
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- $43.00
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2026-08-30
- CAS:148451-96-1
- Purity: 99.77%
- Supply Ability: 10g
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| | Ac-Trp-3,5-bis(trifluoromethyl)benzyl ester Basic information |
| Product Name: | Ac-Trp-3,5-bis(trifluoromethyl)benzyl ester | | Synonyms: | N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROMETHYL)-BENZYL ESTER;N-acetyl-L-tryptophan 3,5-bis*(trifluoromethyl)be;L732138;N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROM ETHYL)BENZ;3,5-bis(trifluoromethyl)benzyl N-acetyltryptophan;N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester,L-732,138;[3,5-Bis(Trifluoromethyl)phenyl]methyl (2S)-2-acetamido-3-(1H-Indol-3-Yl)propanoate;L-Tryptophan, N-acetyl-, [3,5-bis(trifluoromethyl)phenyl]methyl ester | | CAS: | 148451-96-1 | | MF: | C22H18F6N2O3 | | MW: | 472.38 | | EINECS: | | | Product Categories: | | | Mol File: | 148451-96-1.mol |  |
| | Ac-Trp-3,5-bis(trifluoromethyl)benzyl ester Chemical Properties |
| Melting point | 147-148 °C(lit.) | | Boiling point | 554.1±50.0 °C(Predicted) | | density | 1.396±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Soluble to 100 mM in ethanol and to 100 mM in DMSO | | pka | 14.63±0.46(Predicted) | | form | powder | | color | White to off-white |
| | Ac-Trp-3,5-bis(trifluoromethyl)benzyl ester Usage And Synthesis |
| Uses | L-732,138 is a Substance P (SP) receptor antagonist. | | Biological Activity | Potent and highly selective competitive tachykinin NK 1 receptor antagonist (IC 50 = 2.3 nM). | | in vivo | L-732138 (10-4-10-2 mol/kg; intravenous injection; for 15 minutes; male Dunkin-Hartley guinea-pigs) treatment abolishes vagally-induced plasma exudation and significantly inhibits the enhancement by LPS. The LPS-enhanced vagally-induced plasma exudation is not completely inhibited by either L-732138 or SOD pretreatment alone, but is blocked by the combination of both pretreatments[3]. | Animal Model: | Male Dunkin-Hartley guinea-pigs (350-500 g) injected with lipopolysaccharide (LPS)[3] | | Dosage: | 10-4 mol/kg , 10-3 mol/kg and 10-2 mol/kg | | Administration: | Intravenous injection; for 15 minutes | | Result: | Abolished the vagally-induced plasma leakage in tracheobronchial tissues, and dose-dependently inhibited the LPS enhanced vagally-induced plasma exudation in traceobronchial tissues.
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| | IC 50 | NK1: 2.3 nM (IC50) | | storage | Store at RT |
| | Ac-Trp-3,5-bis(trifluoromethyl)benzyl ester Preparation Products And Raw materials |
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