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| | 2,5-Dimethylnitrobenzene Basic information |
| Product Name: | 2,5-Dimethylnitrobenzene | | Synonyms: | 2,5-Dimethylnitrobenzene/Nitro-p-xylene;1,4-DiMethyl-2-nitrobenzene, 95+%;2,5-DIMETHYLNITROBENZENE;2-NITRO-1,4-DIMETHYLBENZENE;2-NITRO-4-XYLENE;1,4-dimethyl-2-nitro-benzen;1-Nitro-2,5-dimethylbenzene;2-Nitro-para-xylene | | CAS: | 89-58-7 | | MF: | C8H9NO2 | | MW: | 151.16 | | EINECS: | 201-920-7 | | Product Categories: | | | Mol File: | 89-58-7.mol |  |
| | 2,5-Dimethylnitrobenzene Chemical Properties |
| Melting point | -25°C | | Boiling point | 121°C 13mm | | density | 1.13 | | refractive index | 1.5400-1.5440 | | Fp | 104℃ | | storage temp. | Sealed in dry,Room Temperature | | form | clear liquid | | color | Light orange to Yellow to Green | | Henry's Law Constant | 3.9×10-1 mol/(m3Pa) at 25℃, Zhang et al. (2010) | | Stability: | Stable. Incompatible with strong bases, strong oxidizing agents. | | CAS DataBase Reference | 89-58-7(CAS DataBase Reference) | | NIST Chemistry Reference | Benzene, 1,4-dimethyl-2-nitro-(89-58-7) | | EPA Substance Registry System | 2-Nitro-p-xylene (89-58-7) |
| Risk Statements | 36/37-39/23/24/25 | | Safety Statements | 26-36/37/39-24/25 | | RIDADR | 1665 | | RTECS | ZE4686600 | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | II | | HS Code | 29042090 | | Toxicity | LD50 orl-rat: 2440 mg/kg 85JCAE -,420,86 |
| | 2,5-Dimethylnitrobenzene Usage And Synthesis |
| Chemical Properties | pale yellow liquid | | Synthesis Reference(s) | Synthesis, p. 690, 1978 DOI: 10.1055/s-1978-24859 | | General Description | Clear pale yellow to amber liquid. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | 2,5-Dimethylnitrobenzene is incompatible with strong oxidizers and strong bases . | | Fire Hazard | 2,5-Dimethylnitrobenzene is probably combustible. | | Safety Profile | Moderately toxic by ingestion.Mutation data reported. When heated to decomposition itemits toxic vapors of NOx. | | Synthesis | GENERAL STEPS: All reactions were carried out in a 50 mL two-necked round-bottomed flask equipped with a water condenser and a magnetic stirrer. In a typical experiment, a mixture of zeolite HBEA-25 (Si/Al = 25, 0.11 g), o-xylene (0.60 mL, 5 mmol), 65% nitric acid (0.68 mL, 10 mmol) with acetic anhydride (5.0 mL) was stirred and reacted for 10 h at room temperature. After completion of the reaction, the zeolite was removed by filtration and the filtrate was washed sequentially with NaHCO3 solution (3 x 10 mL) and distilled water (3 x 10 mL). The organic phase was separated, dried with anhydrous sodium sulfate and filtered to give a straw yellow liquid product. The isomer distribution and yield of the product were estimated by gas chromatography internal standard method based on peak area. The crude product was further purified by column chromatography and structural identification was carried out by comparing the analytical data with real samples. | | References | [1] Russian Journal of Organic Chemistry, 1993, vol. 29, # 3.2, p. 457 - 466
[2] Zhurnal Organicheskoi Khimii, 1993, vol. 29, # 3, p. 546 - 558
[3] Tetrahedron Letters, 1996, vol. 37, # 4, p. 513 - 516
[4] Journal of Fluorine Chemistry, 2008, vol. 129, # 6, p. 524 - 528
[5] Organic Letters, 2018, vol. 20, # 11, p. 3197 - 3201 |
| | 2,5-Dimethylnitrobenzene Preparation Products And Raw materials |
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