2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID

2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID Suppliers list

Company Name:	3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:	18930552037
Email:	3bsc@sina.com

Company Name:	TCI (Shanghai) Development Co., Ltd.
Tel:	021-67121386
Email:	Sales-CN@TCIchemicals.com

2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID manufacturers

2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID Basic information

Product Name:	2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID
Synonyms:	2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID;2-Chloro-4-fluoro-5-nitrobenzoic acid 98%;2-Chloro-4-fluoro-5-nitrobenzoicacid98%;2-chloro-4-fluoro-5-nitrobenzoate;5-Carboxy-4-chloro-2-fluoronitrobenzene;2-Chloro-4-fluoro-5-nitrobenzoic ac;2-Chloro-4-fluoro-5-nitrobenzoic Acid >;Benzoic acid, 2-chloro-4-fluoro-5-nitro-
CAS:	114776-15-7
MF:	C7H3ClFNO4
MW:	219.55
EINECS:	630-233-9
Product Categories:	blocks;Carboxes;FluoroCompounds;NitroCompounds
Mol File:	114776-15-7.mol

2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID Chemical Properties

Melting point	146-150
Boiling point	364.2±42.0 °C(Predicted)
density	1.689±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in methanol.
pka	2.32±0.12(Predicted)
form	Powder
color	White
InChI	InChI=1S/C7H3ClFNO4/c8-4-2-5(9)6(10(13)14)1-3(4)7(11)12/h1-2H,(H,11,12)
InChIKey	SYZKAFCPWNFONG-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC([N+]([O-])=O)=C(F)C=C1Cl
CAS DataBase Reference	114776-15-7

Safety Information

MSDS Information

2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID Usage And Synthesis

Uses	2-Chloro-4-fluoro-5-nitrobenzoic acid is used as pharmaceutical intermediate.
Synthesis	2252-51-9 114776-15-7 The general procedure for the synthesis of 2-chloro-4-fluoro-5-nitrobenzoic acid from 2-chloro-4-fluorobenzoic acid was as follows: 50 g of concentrated sulfuric acid and 0.8 g of the catalyst prepared in Example 1 were added to a reaction flask, followed by the addition of 10 g of 2-chloro-4-fluorobenzoic acid in batches. The reaction mixture was stirred at 25°C for 1 hour. The reaction mixture was cooled to 0°C in an ice bath, and then 5 g of fuming nitric acid was added slowly and dropwise, controlling the reaction temperature between -5 and 8°C. The reaction was continued for 5 to 8 hours until the content of 2-chloro-4-fluorobenzoic acid was less than 0.5%. The reaction mixture was slowly poured into 80 g of crushed ice and the solid product was collected by filtration. The filter cake was washed with 30 g of ice water and subsequently air-dried at 65 °C to give 12.0 g of the white solid product 2-chloro-4-fluoro-5-nitrobenzoic acid in 97.1% yield and 97.2% purity. The isomer of formula (II) was 1.1% by weight.
References	[1] Patent: CN106866684, 2017, A. Location in patent: Paragraph 0131-0132; 0204-0205 [2] Patent: CN106905161, 2017, A. Location in patent: Paragraph 0014; 0015; 0016; 0017 [3] Farmaco, 2004, vol. 59, # 6, p. 463 - 471 [4] Synthesis, 1987, # 10, p. 883 - 887 [5] Patent: US2002/45550, 2002, A1

2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID Preparation Products And Raw materials

Raw materials	1-Chloro-5-fluoro-4-nitro-2-(trichloromethyl)benzene-->2-Chloro-4-fluorobenzoic acid-->Sulfuric acid-->Zirconium oxychloride-->Nitric acid-->Cobalt chloride
Preparation Products	METHYL 2-CHLORO-4-FLUORO-5-NITROBENZOATE-->5-AMino-2-chloro-4-fluoro-benzoic acid Methyl ester

Tag:2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID(114776-15-7) Related Product Information

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