BAY-784
| 中文名称 | BAY-784 |
|---|---|
| 中文同义词 | 化合物 T10475;化合物 BAY-784 |
| 英文名称 | BAY-784 |
| 英文同义词 | BAY-784;BAY1214784;(S)-N-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)-2-cyclopropyl-1-((4-fluorophenyl)sulfonyl)-;BAY784,BAY 784;Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2S)- |
| CAS号 | 1631164-24-3 |
| 分子式 | C29H26ClF4N3O5S2 |
| 分子量 | 672.11 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1631164-24-3.mol |
| 结构式 |  |
BAY-784 性质
| 密度 | 1.60±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | DMSO: 2mg/mL, clear |
| 酸度系数(pKa) | 12.47±0.40(Predicted) |
| 形态 | powder |
| 颜色 | white to beige |
| 旋光度 (Optical Rotation) | [α]/D -120 to -100°, c =0.5 in chloroform-d |
| InChIKey | PZGSYNNVPNLHQG-SANMLTNESA-N |
| SMILES | O=S(CCC1(C2=C(N3S(C4=CC=C(F)C=C4)(=O)=O)C=CC(C(NCC5=C(Cl)C=C(C(F)(F)F)C=N5)=O)=C2)[C@@H]3C6CC6)(CC1)=O |
BAY-784 是一种促性腺激素释放激素受体 (GnRH-R) 拮抗剂探针，对人和大鼠 GnRH-R 的 IC50 分别为 21 和 24 nM。
IC50: 21 nM (human GnRH-R), 24 nM (rat GnRH-R)
BAY-784 (0.5, 3, 10, and 30 mg/kg; 24 hours; single p.o.) suppresses the plasma luteinizing hormone (LH) concentration in ovariectomized (OVX) rats in a dose-dependent manner.
| Animal Model: | OVX rats |
| Dosage: | 0.5, 3, 10, and 30 mg/kg (Pharmacokinetic Analysis) |
| Administration: | Single p.o. |
| Result: |
ED
50
=4.5 mg/kg (4/8 h).
The t 1/2 =13-17 h, 18 h, and 7 h for male Wistar rat, female beagle, and female cynomolgus, respectively. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |