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BAY-784

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Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:BAY-784
CAS:1631164-24-3
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:BAY-784
CAS:1631164-24-3
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Company Name: TargetMol Chemicals Inc.
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CAS:1631164-24-3
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Products Intro: Product Name:BAY-784
CAS:1631164-24-3
Purity:98% Package:10mg;100mg;1g;10g;100g;1kg
Company Name: Guangzhou Younan Technology Co., Ltd  
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BAY-784 manufacturers

  • BAY-784
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  • $558.00
  • 2026-04-20
  • CAS:1631164-24-3
  • Purity: 99.75%
  • Supply Ability: 10g
  • BAY-784
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  • $1520.00
  • 2025-07-25
  • CAS:1631164-24-3
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BAY-784 Basic information
Product Name:BAY-784
Synonyms:BAY-784;BAY1214784;(S)-N-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)-2-cyclopropyl-1-((4-fluorophenyl)sulfonyl)-;BAY784,BAY 784;Spiro[3H-indole-3,4'-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydro-, 1',1'-dioxide, (2S)-
CAS:1631164-24-3
MF:C29H26ClF4N3O5S2
MW:672.11
EINECS:
Product Categories:
Mol File:1631164-24-3.mol
BAY-784 Structure
BAY-784 Chemical Properties
density 1.60±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 2mg/mL, clear
pka12.47±0.40(Predicted)
form powder
color white to beige
Optical Rotation[α]/D -120 to -100°, c =0.5 in chloroform-d
InChIKeyPZGSYNNVPNLHQG-SANMLTNESA-N
SMILESO=S(CCC1(C2=C(N3S(C4=CC=C(F)C=C4)(=O)=O)C=CC(C(NCC5=C(Cl)C=C(C(F)(F)F)C=N5)=O)=C2)[C@@H]3C6CC6)(CC1)=O
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
BAY-784 Usage And Synthesis
UsesBAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively[1].
Biological ActivityBAY-784 is an orally available, non-toxic, potent, and selective antagonist of human Gonadotropin-Releasing Hormone Receptor [hGnRH-R], which is potently active in other species including rate, dogs and cynomolgus monkey. It partially lowered plasma luteinizing hormone levels in humans. BAY-784 exhibits favorable drug metabolism and pharmacokinetic (DMPK) profile thus is suitable for in vivo studies.
in vivo

BAY-784 (0.5, 3, 10, and 30 mg/kg; 24 hours; single p.o.) suppresses the plasma luteinizing hormone (LH) concentration in ovariectomized (OVX) rats in a dose-dependent manner[1].

Animal Model:OVX rats[1]
Dosage:0.5, 3, 10, and 30 mg/kg (Pharmacokinetic Analysis)
Administration:Single p.o.
Result:ED50=4.5 mg/kg (4/8 h).
The t1/2=13-17 h, 18 h, and 7 h for male Wistar rat, female beagle, and female cynomolgus, respectively.
References[1] GnRH-R Antagonist Probe BAY-784.
BAY-784 Preparation Products And Raw materials
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